3.4.6
Cardiovascular Disease
Atheromas
Atheromas
Atheromas are the deposition of materials in the walls of the arteries causing a blockage. Atheromas can cause a number of cardiovascular diseases.
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Deposition
Deposition
- The endothelium of arteries can become damaged by the deposition of white blood cells and lipids.
- If white blood cells and fatty materials continue to be deposited in the artery walls, the materials will begin to form hard, fibrous plaque.
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Narrow lumen
Narrow lumen
- As the fibrous plaque builds up, the lumen of the artery becomes narrower.
- The flow of blood through the arteries is restricted.
- The narrower lumen also increases blood pressure.
- The presence of the fibrous plaque is called an atheroma.
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Coronary heart disease
Coronary heart disease
- Atheromas can cause diseases of the heart.
- Coronary heart disease (CHD) is a type of disease that is associated with many atheromas.
Aneurysm & Thrombosis
Aneurysm & Thrombosis
Atheromas can increase the risk of two types of diseases:
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Aneurysm
Aneurysm
- Atheromas damage the artery walls and increase blood pressure.
- The increased blood pressure can cause the elastic fibres in the artery wall to swell in balloon-like structure.
- This swelling is an aneurysm.
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Thrombosis
Thrombosis
- Atheromas can damage the artery walls, causing them to burst open.
- Platelets are transported in the bloodstream to the damaged part of the artery wall.
- The platelets accumulate and form a clot called a thrombus.
- A thrombus can block blood flow in the artery.
Risk Factors
Risk Factors
There are certain risk factors that can increase the chance of developing cardiovascular disease. These include:
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Diet
Diet
- A diet that is high in saturated fat and salt can lead to high blood cholesterol levels.
- Cholesterol in the blood can contribute to the formation of atheromas in the arteries.
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Smoking
Smoking
- Smoking cigarettes increases the risk of high blood pressure.
- Carbon monoxide found in cigarettes reduces the amount of oxygen that can be carried by haemoglobin in the blood.
- Reduced transport of oxygen can increase the risk of a heart attack.
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High blood pressure
High blood pressure
- High blood pressure can be inherited or it can be caused by being overweight and consuming excessive alcohol.
- High blood pressure can contribute to the formation of atheromas.
1Biological Molecules
1.1Monomers & Polymers
1.2Carbohydrates
1.3Lipids
1.4Proteins
1.4.1The Peptide Chain
1.4.2Investigating Proteins
1.4.3Primary & Secondary Protein Structure
1.4.4Tertiary & Quaternary Protein Structure
1.4.5Enzymes
1.4.6Factors Affecting Enzyme Activity
1.4.7Enzyme-Controlled Reactions
1.4.8End of Topic Test - Lipids & Proteins
1.4.9A-A* (AO3/4) - Enzymes
1.4.10A-A* (AO3/4) - Proteins
1.5Nucleic Acids
1.6ATP
1.7Water
1.8Inorganic Ions
2Cells
2.1Cell Structure
2.2Mitosis & Cancer
2.3Transport Across Cell Membrane
2.4Cell Recognition & the Immune System
3Substance Exchange
3.1Surface Area to Volume Ratio
3.2Gas Exchange
3.3Digestion & Absorption
4Genetic Information & Variation
4.1DNA, Genes & Chromosomes
4.2DNA & Protein Synthesis
4.3Mutations & Meiosis
4.4Genetic Diversity & Adaptation
4.5Species & Taxonomy
4.6Biodiversity Within a Community
4.7Investigating Diversity
5Energy Transfers (A2 only)
5.1Photosynthesis
5.1.1Overview of Photosynthesis
5.1.2Photoionisation of Chlorophyll
5.1.3Production of ATP & Reduced NADP
5.1.4Cyclic Photophosphorylation
5.1.5Light-Independent Reaction
5.1.6A-A* (AO3/4) - Photosynthesis Reactions
5.1.7Limiting Factors
5.1.8Photosynthesis Experiments
5.1.9End of Topic Test - Photosynthesis
5.1.10A-A* (AO3/4) - Photosynthesis
5.2Respiration
5.3Energy & Ecosystems
6Responding to Change (A2 only)
6.1Nervous Communication
6.2Nervous Coordination
6.3Muscle Contraction
6.4Homeostasis
6.4.1Overview of Homeostasis
6.4.2Blood Glucose Concentration
6.4.3Controlling Blood Glucose Concentration
6.4.4End of Topic Test - Blood Glucose
6.4.5Primary & Secondary Messengers
6.4.6Diabetes Mellitus
6.4.7Measuring Glucose Concentration
6.4.8Osmoregulation
6.4.9Controlling Blood Water Potential
6.4.10ADH
6.4.11End of Topic Test - Diabetes & Osmoregulation
6.4.12A-A* (AO3/4) - Homeostasis
7Genetics & Ecosystems (A2 only)
7.1Genetics
7.2Populations
7.3Evolution
7.3.1Variation
7.3.2Natural Selection & Evolution
7.3.3End of Topic Test - Populations & Evolution
7.3.4Types of Selection
7.3.5Types of Selection Summary
7.3.6Overview of Speciation
7.3.7Causes of Speciation
7.3.8Diversity
7.3.9End of Topic Test - Selection & Speciation
7.3.10A-A* (AO3/4) - Populations & Evolution
8The Control of Gene Expression (A2 only)
8.2Gene Expression
8.2.1Stem Cells
8.2.2Stem Cells in Disease
8.2.3End of Topic Test - Mutation & Gene Epression
8.2.4A-A* (AO3/4) - Mutation & Stem Cells
8.2.5Regulating Transcription
8.2.6Epigenetics
8.2.7Epigenetics & Disease
8.2.8Regulating Translation
8.2.9Experimental Data
8.2.10End of Topic Test - Transcription & Translation
8.2.11Tumours
8.2.12Correlations & Causes
8.2.13Prevention & Treatment
8.2.14End of Topic Test - Cancer
8.2.15A-A* (AO3/4) - Gene Expression & Cancer
8.3Genome Projects
Jump to other topics
1Biological Molecules
1.1Monomers & Polymers
1.2Carbohydrates
1.3Lipids
1.4Proteins
1.4.1The Peptide Chain
1.4.2Investigating Proteins
1.4.3Primary & Secondary Protein Structure
1.4.4Tertiary & Quaternary Protein Structure
1.4.5Enzymes
1.4.6Factors Affecting Enzyme Activity
1.4.7Enzyme-Controlled Reactions
1.4.8End of Topic Test - Lipids & Proteins
1.4.9A-A* (AO3/4) - Enzymes
1.4.10A-A* (AO3/4) - Proteins
1.5Nucleic Acids
1.6ATP
1.7Water
1.8Inorganic Ions
2Cells
2.1Cell Structure
2.2Mitosis & Cancer
2.3Transport Across Cell Membrane
2.4Cell Recognition & the Immune System
3Substance Exchange
3.1Surface Area to Volume Ratio
3.2Gas Exchange
3.3Digestion & Absorption
4Genetic Information & Variation
4.1DNA, Genes & Chromosomes
4.2DNA & Protein Synthesis
4.3Mutations & Meiosis
4.4Genetic Diversity & Adaptation
4.5Species & Taxonomy
4.6Biodiversity Within a Community
4.7Investigating Diversity
5Energy Transfers (A2 only)
5.1Photosynthesis
5.1.1Overview of Photosynthesis
5.1.2Photoionisation of Chlorophyll
5.1.3Production of ATP & Reduced NADP
5.1.4Cyclic Photophosphorylation
5.1.5Light-Independent Reaction
5.1.6A-A* (AO3/4) - Photosynthesis Reactions
5.1.7Limiting Factors
5.1.8Photosynthesis Experiments
5.1.9End of Topic Test - Photosynthesis
5.1.10A-A* (AO3/4) - Photosynthesis
5.2Respiration
5.3Energy & Ecosystems
6Responding to Change (A2 only)
6.1Nervous Communication
6.2Nervous Coordination
6.3Muscle Contraction
6.4Homeostasis
6.4.1Overview of Homeostasis
6.4.2Blood Glucose Concentration
6.4.3Controlling Blood Glucose Concentration
6.4.4End of Topic Test - Blood Glucose
6.4.5Primary & Secondary Messengers
6.4.6Diabetes Mellitus
6.4.7Measuring Glucose Concentration
6.4.8Osmoregulation
6.4.9Controlling Blood Water Potential
6.4.10ADH
6.4.11End of Topic Test - Diabetes & Osmoregulation
6.4.12A-A* (AO3/4) - Homeostasis
7Genetics & Ecosystems (A2 only)
7.1Genetics
7.2Populations
7.3Evolution
7.3.1Variation
7.3.2Natural Selection & Evolution
7.3.3End of Topic Test - Populations & Evolution
7.3.4Types of Selection
7.3.5Types of Selection Summary
7.3.6Overview of Speciation
7.3.7Causes of Speciation
7.3.8Diversity
7.3.9End of Topic Test - Selection & Speciation
7.3.10A-A* (AO3/4) - Populations & Evolution
8The Control of Gene Expression (A2 only)
8.2Gene Expression
8.2.1Stem Cells
8.2.2Stem Cells in Disease
8.2.3End of Topic Test - Mutation & Gene Epression
8.2.4A-A* (AO3/4) - Mutation & Stem Cells
8.2.5Regulating Transcription
8.2.6Epigenetics
8.2.7Epigenetics & Disease
8.2.8Regulating Translation
8.2.9Experimental Data
8.2.10End of Topic Test - Transcription & Translation
8.2.11Tumours
8.2.12Correlations & Causes
8.2.13Prevention & Treatment
8.2.14End of Topic Test - Cancer
8.2.15A-A* (AO3/4) - Gene Expression & Cancer
8.3Genome Projects
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