Human Gas Exchange

Structure

Human gas exchange takes place in specialised organs called the lungs. The lungs are specialised for the quick exchange of oxygen and carbon dioxide with the bloodstream.

Structure

Trachea

The trachea is the entrance to the human gas exchange system.
When you breathe in, air flows through the trachea.
Ridges of cartilage surround the front of the trachea to provide protection and structure.
- There is no cartilage at the back of the trachea so that the oesophagus (the tube where food travels) is not constricted.

Bronchi & bronchioles

The trachea divides into two bronchi.
Air flows along each bronchus to a lung.
The bronchi are made from cartilage and smooth muscle.
Each bronchus divides into many smaller bronchioles.
- The many bronchioles branch throughout the the lungs into small air-sacs called alveoli.

Alveoli

The alveoli are sacs that fill with air when you breathe in.
Oxygen in the alveoli diffuses into the bloodstream and carbon dioxide in the bloodstream diffuses into the alveoli.
There are millions of alveoli in the lungs
The alveoli provide a large surface area for gas exchange.

Control of ventilation

Ventilation is controlled by the ribcage, intercostal muscles and the diaphragm.
When you breathe in, these structures move to allow the lungs to fill with air.
When you breathe out, these structures move to allow air to leave the lungs.

Columnar epithelium

The trachea, bronchi, and large bronchioles are lined with columnar ciliated epithelium.
Goblet cells are the mucus-secreting cells of ciliated epithelium. This mucus traps dust, particles, and pathogens.
Ciliated cells are columnar in shape. They have multiple, thin projections from their surface ('cilia").
- Cilia contract and "waft" the mucus produced by goblet cells up the trachea to the back of the throat, where it is swallowed.
Any swallowed pathogens are destroyed by stomach acid.

Alveoli

Alveoli are the millions of air sacs within the lungs where gases are exchanged with the bloodstream. They provide a large surface area for gas exchange.

Capillaries

Each alveolus is surrounded by a network of capillaries.
The many capillaries provide a large surface area for gas exchange between the alveoli and the bloodstream.

Alveolar epithelium

The alveolar epithelium is made up of a single layer of squamous epithelial cells that line the walls of the alveoli.
Squamous epithelial cells are generally round, flat, and have a small, centrally located nucleus.
In the alveoli, the squamous cells are arranged in a single layer to facilitate gas diffusion.
- The squamous epithelium provides a very short diffusion distance from the alveoli to the capillaries which maximises the rate of gas exchange.

Concentration gradient

The capillaries supply carbon dioxide to the alveoli and oxygen is rapidly carried away from the alveoli.
The quick transport of gases in the bloodstream maintains a steep concentration gradient of oxygen and carbon dioxide.
- The steep concentration gradient allows quick diffusion of gases into and out of the bloodstream.

Smoking and the Respiratory System

Smoking can causes a range of very serious diseases. Cigarette smoke contains harmful chemical such as nicotine, carbon monoxide and carcinogens (cancer-causing chemicals).

Bronchitis

When smoke is breathed in, it damages the cilia cells of the airways.
This means the cilia can't waft away the mucus produced by goblet cells, and the mucus builds up.
This can leads to bronchitis, where the airways are partly blocked with mucus.

Emphysema

Smoking damages the elastic fibres in the alveoli. This prevents elastic recoil and causes overinnflation of the lungs.
This can cause emphysema, where gas exchange can't happen efficiently, causing shortness of breath.
Together bronchitis and emphysema form a condition called chronic obtrusive pulmonary disease (COPD).
- Symptoms include a cough, breathlessness, and wheezing.

Cancers

The carcinogens in the tar in cigarettes can cause tumours to form in the airways.
- Smoking can cause mouth, throat and lung cancers.

Heart disease and strokes

Nicotine is very addictive and puts strain on the heart.
- Nicotine acts as a stimulant and causes the heart to beat faster at with greater force. This can increase blood pressure.
Carbon monoxide reduces the ability of red blood cells to carry oxygen, which can also put strain on the heart. Carbon monoxide binds to haemaglobin with 200x the affinity of oxygen.
Both of these substances can cause heart disease and strokes.

1Principles of Science I

1.1Structure & Bonding

1.1.1Atomic Model

1.1.2Electron Shells, Sub-Shells & Orbitals

1.1.3Ionic Bonding

1.1.4Representing Ionic Bonds

1.1.5Covalent Bonding

1.1.6Representing Covalent Bonds

1.1.7Metallic Bonding

1.1.8Intermolecular Forces

1.1.9Intermolecular Forces 2

1.1.10End of Topic Test - Bonding

1.1.11Relative Masses

1.1.12The Mole

1.1.13Molar Calculations

1.1.14Molar Calculations 2

1.1.15Empirical & Molecular Formulae

1.1.16Balanced Equations

1.1.17Percentage Yield

1.1.18End of Topic Test - Amount of Substance

1.2Properties of Substances

1.2.1The Periodic Table

1.2.2Ionisation Energy

1.2.3Factors Affecting Ionisation Energies

1.2.4Trends of Ionisation

1.2.5Trends in the Periodic Table

1.2.6Polarity

1.2.7Metals & Non-Metals

1.2.8Alkali Metals

1.2.9Alkaline Earth Metals

1.2.10Reactivity of Alkaline Earth Metals

1.2.11Redox

1.2.12Transition Metals

1.2.13Redox Reactions of Transition Metals

1.3Cell Structure & Function

1.3.1Introduction to Cells

1.3.2Prokaryotes

1.3.3Organelles of Eukaryotic Cells

1.3.4Organelles of Eukaryotic Cells 2

1.3.5Organelles in Plant Cells

1.3.6Microscopy

1.3.7End of Topic Test - Cell Structure

1.4Cell Specialisation

1.4.1Cell Specialisation

1.4.2Blood Cells

1.4.3Plant Cells

1.4.4Gametes

1.5Tissue Structure & Function

1.5.1Human Gas Exchange

1.5.2Blood Vessels

1.5.3Atherosclerosis

1.5.4Skeletal Muscle

1.5.5Slow & Fast Twitch Fibres

1.5.6Neurones

1.5.7Speed of Transmission

1.5.8Action Potentials

1.5.9End of Topic Test - Neurones & Action Potentials

1.5.10Synapses

1.5.11Types of Synapse

1.5.12Medical Application

1.5.13End of Topic Test - Synapses

1.5.14Chemical Brain Imbalances

1.5.15Effect of Drugs on the Brain

1.6Working with Waves

1.6.1Progressive Waves

1.6.2Wave Speed & Phase Difference

1.6.3Longitudinal & Transverse Waves

1.6.4Stationary Waves

1.6.5Stationary Waves 2

1.6.6Applications of Stationary Waves

1.6.7Interference

1.6.8Diffraction

1.6.9Diffraction Gratings

1.6.10Application of Diffraction Gratings

1.7Waves in Communication

1.7.1Refraction at a Plane Surface

1.7.2Internal Reflection & Fibre Optics

1.7.3Applications of Total Internal Reflection

1.7.4Properties

1.7.5Gamma, X-Ray & UV Light

1.7.6Visible Light

1.7.7Infrared, Microwave & Radio Waves

1.7.8Intensity

1.7.9Digital & Analogue Signals

1.7.10Communication Channels

2Practical Scientific Procedures and Techniques

2.1Titration

2.1.1pH Curves & Titrations

2.1.2pH Curves & Titrations 2

2.1.3Buffer Solutions

2.2Colorimetry

2.2.1Measuring Rates

2.2.2Beer-Lambert Law

2.3Chromatography

2.3.1Overview of Chromatography

2.3.2Thin-Layer Chromatography

2.3.3Column Chromatography

2.3.4Gas Chromatography

3Science Investigation Skills

3.1Scientific Processes

3.1.1Aims, Hypotheses & Sampling

3.1.2Pilot Studies & Design

3.1.3Ethics

3.1.4Variables & Control

3.1.5Demand Characteristics & Investigator Effects

3.1.6Features of Science

3.1.7Scientific Report

3.1.8Scientific Report 2

3.2Data Handling & Analysis

3.2.1Types of Data

3.2.2Descriptive Statistics

3.2.3Presentation & Display of Data

3.3Enzymes in Action

3.3.1Overview of Protein Structure

3.3.2Enzymes

3.3.3Factors Affecting Enzyme Activity

3.3.4Enzyme-Controlled Reactions

3.4Diffusion

3.4.1Diffusion

3.5Plants & Their Environment

3.5.1Factors Affecting Plant Growth

3.5.2Measuring Number & Distribution of Species

3.6Energy Content in Fuels

3.6.1Fractions

3.6.2Burning Hydrocarbons

3.6.3Combustion

3.6.4Energy

3.6.5Energy at Home

3.6.6Calorimetry

3.7Electrical Circuits

3.7.1Circuit Diagrams & Components

3.7.2Diodes, LDRs & Thermistors

3.7.3Resistance

3.7.4Electrical Work

3.7.5Ohm's Law

3.7.6Domestic Uses of Electricity

3.7.7Fuses

4Principles of Science II

4.1Extracting Elements

4.1.1Atom Economy

4.2Relating Properties to use of Substances

4.2.1Group 2 Chemistry

4.2.2End of Topic Test - Group 2

4.2.3Electrolysis

4.2.4Electrolysis Examples

4.2.5Extracting Metals

4.2.6Transition Metals

4.2.7Variable Oxidation States

4.2.8Heterogeneous Catalysts

4.2.9Homogeneous Catalysts

4.3Organic Chemistry

4.3.1Naming Compounds

4.3.2Functional Groups

4.3.3Isomerism

4.3.4Hydrocarbons

4.3.5Structure of Alkanes

4.3.6Boiling Points of Alkanes

4.3.7Alkenes

4.3.8Curly Arrows & Mechanisms

4.3.9Cracking

4.3.10Combustion

4.3.11Free Radical Substitution of Alkanes

4.3.12Electrophilic Addition of Alkenes

4.4Energy Changes in Industry

4.4.1The Kelvin Scale

4.4.2Enthalpy Changes

4.4.3Calorimetry

4.4.4Bond Enthalpies

4.4.5Hess' Law

4.5The Circulatory System

4.5.1The Circulatory System

4.5.2Blood Vessels

4.5.3Blood Transfusion & the ABO Rhesus System

4.5.4The Heart

4.5.5The Cardiac Cycle

4.5.6Cardiac Output

4.5.7Coordination of Heart Action

4.5.8Heart Dissection

4.5.9Controlling Heart Rate

4.5.10Electrocardiograms

4.5.11Cardiovascular Disease

4.5.12Investigating Heart Rates

4.6Ventilation & Gas Exchange

4.6.1Human Gas Exchange

4.6.2Ventilation

4.6.3Measuring Gas Exchange

4.6.4Controlling Ventilation Rate

4.6.5Lung Disease

4.6.6Lung Disease Data

4.7Urinary System

4.7.1Kidneys & Control of Water Balance

4.7.2Kidneys & Osmoregulation

4.7.3Kidneys & Blood Pressure

4.7.4Urine

4.7.5Kidney Failure & Urinalysis

4.7.6Dialysis

4.7.7Transplants

4.8Cell Transport

4.8.1Cell Membrane Structure

4.8.2Diffusion

4.8.3Osmosis

4.8.4Active Transport

4.9Thermal Physics

4.9.1Power & Efficiency

4.9.2Work & Energy

4.9.3Conservation of Energy

4.9.4Pressure

4.9.5First Law of Thermodynamics

4.9.6Second Law of Thermodynamics

4.9.7Heat Engines, Heat Pumps & Refrigerators

4.9.8Non-Flow Processes

4.9.9p-V Diagrams

4.9.10Ideal Gases

4.9.11Ideal Gases 2

4.9.12Thermal Energy Transfer

4.9.13Thermal Energy Transfer Experiments

4.10Materials

4.10.1Density

4.10.2Stress & Strain

4.10.3Properties of Materials

4.10.4Elasticity

4.10.5Plasticity

4.10.6Energy in Materials

4.10.7Young Modulus

4.11Fluids

4.11.1Fluid Flow

4.11.2Viscosity

4.11.3Density

4.11.4Continuity Equation

4.11.5Bernoulli's Equation

4.11.6Non-Newtonian Fluids

5Contemporary Issues in Science

5.1Contemporary Issues in Science

5.1.1Sustainability

5.1.2Genetic Engineering

5.1.3Uses of Genetic Modification

5.1.4Stem Cell Therapy

5.1.5Cloning

5.1.6Cloning 2

5.1.7Nanotechnology

5.1.8Ecosystems

5.2Analysing Scientific Information

5.2.1Validity

5.2.2Peer Review

Jump to other topics