7.1.4

DNA Replication - Summary

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DNA Replication Summary

There's a lot to take in, huh? Let's re-summarize DNA replication below - you got this :-)

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Summary - 1

  1. DNA unwinds at the origin of replication.
  2. Helicase opens up the DNA-forming replication forks; these are extended bidirectionally.
  3. Single-strand binding proteins coat the DNA around the replication fork to prevent rewinding of the DNA.
  4. Topoisomerase binds at the region ahead of the replication fork to prevent supercoiling.
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Summary - 2

  1. Primase synthesizes RNA primers complementary to the DNA strand.
  2. DNA polymerase starts adding nucleotides to the 3'-OH end of the primer.
  3. Elongation of both the lagging and the leading strand continues.
  4. RNA primers are removed by exonuclease activity.
  5. Gaps are filled by DNA pol by adding dNTPs.
  6. The gap between the two DNA fragments is sealed by DNA ligase, which helps in the formation of phosphodiester bonds.

Jump to other topics

1Cell Biology

2Molecular Biology

3Genetics

4Ecology

5Evolution & Biodiversity

6Human Physiology

7AHL: Nucleic Acids

8AHL: Metabolism, Cell Respiration & Photosynthesis

9AHL: Plant Biology

9.1Transport in the Xylem of Plants

9.2Transport in the Phloem of Plants

9.3Growth in Plants

10AHL: Genetics & Evolution

11AHL: Animal Physiology

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