Skeletal Muscle
Biology: Cambridge International A Level, topic 15.1.10
Muscle Fibres
The structure of skeletal muscles is specialised for contraction. Skeletal muscle is a type of striated muscle.

Muscle fibres
- Skeletal muscle consists of many bundles of muscle fibres.
- Muscle fibres are long, specialised cells.

Sarcolemma
- The membrane of muscle fibres is called the sarcolemma.
- The sarcolemma folds inwards to the sarcoplasm (muscle fibre cytoplasm) at certain points.
- The inwards folds are called transverse (T) tubules. The tubules are very important in initiating muscle contraction.

Sarcoplasmic reticulum
- The sarcoplasmic reticulum (SR) is an organelle in the sarcoplasm.
- The SR is a store for calcium (Ca2+) ions. This is important in muscle contraction.

Mitochondria and nuclei
- Muscle fibres also have many mitochondria and nuclei.
- The mitochondria provide lots of ATP to power muscle contraction.

Myofibrils
- Myofibrils are cylindrical organelles that run along the length of muscle fibres.
- Myofibrils are the site of muscle contraction.
Myofibrils
Myofibrils are cylindrical organelles in muscle fibres. Myofibril structure is highly specialised for muscle contraction.

Sarcomere
- Myofibrils are made of multiple units that run end-to-end along the myofibril. These units are called sarcomeres.
- The end of a sarcomere is called the Z-line.

Myofilaments
- Sarcomeres are made from two types of myofilaments.
- The two myofilaments slide past each other. This movement is what makes muscles contract.
- The two types of myofilaments are:
- Thick myofilaments - made of myosin protein.
- Thin myofilaments - made of actin protein.

Myosin filaments
- Myosin and actin filaments are arranged in an alternating pattern in sarcomeres.
- Thick myosin filaments overlap with the thin actin filaments at each end.
- The overlapping region is called the A-band.
- The region with only myosin filament is called the H-zone.

Actin filaments
- Thin actin filaments only overlap with myosin filaments in the middle of the sarcomere. The middle is called the M-line.
- The region with only actin filament is called the I-band.
Test yourself on Skeletal Muscle
Which of these are NOT a feature of muscle fibres?
Which of the following statements about myofibrils are true?
What is the middle of the sarcomere called?
Which of the following is NOT a structure in myofibrils?