Source: https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-3-2-aerobic-respiration [Revision notes](https://senecalearning.com/en-gb/revision-notes.md) › [IB Diploma](https://senecalearning.com/en-gb/revision-notes/ib-diploma.md) › [Biology](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology.md) › [Biology: IB Diploma](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma.md) › Aerobic Respiration # Aerobic Respiration Biology: IB Diploma Higher Level, topic 9.3.2 ## The Link Reaction Pyruvate can be used in aerobic respiration by converting it to acetyl coenzyme A. This process is called the link reaction and it takes place in the matrix of the mitochondria. ### Decarboxylation ![Decarboxylation](https://image-v2.cdn.app.senecalearning.com/2019-01/1e776f86-7498-4363-99bf-66f1d38d7b66/Link%20Reaction.png) - Pyruvate is first actively transported from the cytoplasm across the mitochondrial membrane and into the matrix of the mitochondria. - In the mitochondrial matrix, pyruvate is decarboxylated and dehydrogenated to acetate, which is a two-carbon molecule. - CO2 is produced as a by-product. - NAD is reduced to NADH. ### Coenzyme A ![Coenzyme A](https://image-v2.cdn.app.senecalearning.com/2019-01/1e776f86-7498-4363-99bf-66f1d38d7b66/Link%20Reaction.png) - Acetate then combines with coenzyme A (CoA) to produce acetyl coenzyme A. - Acetyl coenzyme A is used in the Krebs cycle (the next stage of aerobic respiration). - The link reaction links glycolysis to the Krebs cycle. ### Net gain ![Net gain](https://image-v2.cdn.app.senecalearning.com/2019-01/1e776f86-7498-4363-99bf-66f1d38d7b66/Link%20Reaction.png) - The net gain from the link reaction is: - 1 CO2 molecule. - 1 NADH molecule. ## The Krebs Cycle The Krebs cycle takes place in the matrix of the mitochondria. The products of the cycle are two coenzymes (NADH and FADH2), ATP and CO2. ### The Krebs Cycle ![The Krebs Cycle](https://image-v2.cdn.app.senecalearning.com/2018-08/cd6cda33-e266-4bee-b3d4-d7b51057dfad/respiration-Krebs-Cycle.png) ### Acetyl coenzyme A (coA) ![Acetyl coenzyme A (coA)](https://image-v2.cdn.app.senecalearning.com/2018-08/cd6cda33-e266-4bee-b3d4-d7b51057dfad/respiration-Krebs-Cycle.png) - Acetyl coenzyme A acts as a carrier for the two-carbon acetyl group. It reacts with oxaloacetate (a four-carbon molecule) to produce citrate (a six-carbon molecule). - CoA is now available to be recycled and reused in the link reaction. - The production of citrate allows the Krebs cycle to begin. ### 6C → 5C ![6C → 5C](https://image-v2.cdn.app.senecalearning.com/2018-08/cd6cda33-e266-4bee-b3d4-d7b51057dfad/respiration-Krebs-Cycle.png) - Citrate is converted to a five-carbon molecule (5C) by decarboxylation and dehydrogenation. - CO2 is produced as a by-product. - NAD is reduced to NADH. ### 5C → 4C ![5C → 4C](https://image-v2.cdn.app.senecalearning.com/2018-08/cd6cda33-e266-4bee-b3d4-d7b51057dfad/respiration-Krebs-Cycle.png) - The five-carbon molecule is decarboxylated and dehydrogenated again to a four-carbon compound. - CO2 is produced. - NAD is reduced to NADH. - ATP is also produced by substrate-level phosphorylation. ### Regeneration of oxaloacetate ![Regeneration of oxaloacetate](https://image-v2.cdn.app.senecalearning.com/2018-08/cd6cda33-e266-4bee-b3d4-d7b51057dfad/respiration-Krebs-Cycle.png) - This 4C molecule is then dehydrogenated again to produce another molecule of NADH. FAD is also reduced to FADH2. - No decarboxylation takes place at this stage. - These intermediate reactions regenerate oxaloacetate. This allows the cycle to continue again. ### Net gain ![Net gain](https://image-v2.cdn.app.senecalearning.com/2018-09/94612f5c-c44c-4efa-ae70-0734a41bfbbb/Krebs-Cycle-aerobic-respiration-.png) - The net gain of the Krebs cycle is: - 2 CO2 molecules. - 3 NADH molecules. - 1 ATP molecule. - 1 FADH2 molecules. - For each molecule of glucose, there are two cycles (this is because two molecules of pyruvate are produced in glycolysis). ### Other respiratory substrates ![Other respiratory substrates](https://image-v2.cdn.app.senecalearning.com/2018-08/418b7d32-336b-4b07-8ddb-c83d044b977c/Amino%20Acid.jpg) - Fatty acids and amino acids can also be used as respiratory substrates in aerobic respiration. - The substrates are converted to molecules that can easily enter the Krebs cycle. ## Oxidative Phosphorylation Oxidative phosphorylation is the final stage in aerobic respiration. ### Inner mitochondrial membrane ![Inner mitochondrial membrane](https://image-v2.cdn.app.senecalearning.com/2018-09/ca21ff48-d523-4ce5-8df6-4a773f2fe7b0/cell-organelle-mitochondrion-mitochondria-energy-.jpg) - Oxidative phosphorylation takes place at the inner mitochondrial membrane. - There are several features of the membrane that allows production of ATP on a large scale: - Three electron carrier proteins (electron transport chain, ETC). - ATP synthase enzyme. - The space between the inner and outer mitochondrial membranes is called the intermembrane space. ### Electron transport chain ![Electron transport chain](https://image-v2.cdn.app.senecalearning.com/courseImages/chemistry/8.3.1%20Identifying%20ions%201/chain-2364826_640-min.jpg) - NADH and FADH2 (from the Krebs cycle) are oxidised by the first electron carrier protein in the inner mitochondrial membrane. - This initiates oxidative phosphorylation because NADH and FADH2 release two protons and two electrons each. - The electrons are then transferred along the ETC. ### Proton gradient ![Proton gradient](https://image-v2.cdn.app.senecalearning.com/2018-08/aea9d040-6818-4a1e-b307-fda8e8376eee/atp-synthase.jpg) - As the electrons move down the ETC, they lose energy. - This energy pumps the protons from NADH and FADH2 into the intermembrane space. - This creates a proton gradient (also known as an electrochemical gradient). ### Chemiosmosis ![Chemiosmosis](https://image-v2.cdn.app.senecalearning.com/2018-08/aea9d040-6818-4a1e-b307-fda8e8376eee/atp-synthase.jpg) - The protons diffuse down the concentration gradient through the ATP synthase enzyme. - As protons flow through the ATP synthase, energy is released. - This energy converts ADP and inorganic phosphate to ATP. - This process is called chemiosmosis. ### The final electron acceptor ![The final electron acceptor](https://image-v2.cdn.app.senecalearning.com/courseImages/chemistry/(s)%202.1.4.3%20-%20Covalent%20bonding%20in%20oxygen%20(1).png) - After the electrons have reached the end of the ETC and protons have flowed through the ATP synthase enzyme, they combine with O2 to form water (H2O). - Oxygen is called the final electron acceptor for this reason. ## Test yourself on Aerobic Respiration - Where does the link reaction take place? - Which of the following statements about the link reaction are true? - What is the name of the reaction that happens after glycolysis and before the Krebs cycle in aerobic respiration? - Where does the Krebs cycle take place? - Which of the following statements about the Krebs cycle are true? [Practise this topic for free](https://app.senecalearning.com/classroom/course/549189f7-f13a-4c5c-b80c-ea1bd3036d78/section/1ad1630c-581b-400a-a762-26df9809914c/session) - Previous topic: [9.3.1 Glycolysis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-3-1-glycolysis.md) - Next topic: [9.4.1 Light-Dependent Reaction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-1-light-dependent-reaction.md) ## Biology: IB Diploma Higher Level contents ### 1 Unity & Diversity - Molecules - 1.1 Water - [1.1.1 The Importance of Water](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-1-the-importance-of-water.md) - [1.1.2 The Structure of Water](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-2-the-structure-of-water.md) - [1.1.3 The Properties of Water](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-3-the-properties-of-water.md) - [1.1.4 IB Multiple Choice - Water & Hydrogen Bonding](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-4-ib-multiple-choice-water-and-hydrogen-bonding.md) - [1.1.5 Extended Response - Water](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-5-extended-response-water.md) - 1.2 DNA Structure & Replication - [1.2.1 DNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-1-dna.md) - [1.2.2 RNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-2-rna.md) - [1.2.3 Semi-Conservative DNA Replication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-3-semi-conservative-dna-replication.md) - [1.2.4 DNA Replication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-4-dna-replication.md) - [1.2.5 DNA Replication - Summary](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-5-dna-replication-summary.md) - [1.2.6 IB Multiple Choice - DNA Replication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-6-ib-multiple-choice-dna-replication.md) - 1.3 Transcription & Gene Expression - [1.3.1 Introduction to Transcription & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-1-introduction-to-transcription-and-protein-synthesis.md) - [1.3.2 Types of RNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-2-types-of-rna.md) - [1.3.3 Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-3-transcription.md) - [1.3.4 RNA Processing in Eukaryotes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-4-rna-processing-in-eukaryotes.md) - [1.3.5 IB Multiple Choice - Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-5-ib-multiple-choice-transcription.md) - 1.4 Translation - [1.4.1 Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-4-1-translation.md) - [1.4.2 Retroviruses](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-4-2-retroviruses.md) - [1.4.3 Scientific Practices: Coronavirus](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-4-3-scientific-practices-coronavirus.md) - [1.4.4 IB Multiple Choice - Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-4-4-ib-multiple-choice-translation.md) ### 2 Unity & Diversity - Cells - 2.1 The Origin of Cells - [2.1.1 Origins - Endosymbiosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-1-1-origins-endosymbiosis.md) - 2.2 Introduction to Cells - [2.2.1 Introduction to Cells](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-1-introduction-to-cells.md) - [2.2.2 Cell Size & Surface Area](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-2-cell-size-and-surface-area.md) - [2.2.3 Surface Area to Volume Ratio](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-3-surface-area-to-volume-ratio.md) - [2.2.4 Eukaryotic vs Prokaryotic Cells](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-4-eukaryotic-vs-prokaryotic-cells.md) - [2.2.5 Stem Cells](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-5-stem-cells.md) - [2.2.6 Stem Cells in Disease](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-6-stem-cells-in-disease.md) - 2.3 Ultrastructure of Cells - [2.3.1 Golgi, Lysosomes & Ribosomes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-3-1-golgi-lysosomes-and-ribosomes.md) - [2.3.2 Cell Walls & Vacuole](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-3-2-cell-walls-and-vacuole.md) - [2.3.3 Prokaryotes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-3-3-prokaryotes.md) - [2.3.4 Binary Fission](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-3-4-binary-fission.md) - 2.4 Cell Division - [2.4.1 The Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-1-the-cell-cycle.md) - [2.4.2 Mitosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-2-mitosis.md) - [2.4.3 Regulation of the Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-3-regulation-of-the-cell-cycle.md) - [2.4.4 End of Topic Quiz - The Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-4-end-of-topic-quiz-the-cell-cycle.md) - [2.4.5 IB Multiple Choice - The Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-5-ib-multiple-choice-the-cell-cycle.md) - [2.4.6 Extended Response - Mitosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-6-extended-response-mitosis.md) - 2.5 Structure of DNA & RNA - [2.5.1 DNA & RNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-5-1-dna-and-rna.md) - 2.6 DNA Replication, Transcription & Translation - [2.6.1 Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-1-protein-synthesis.md) - [2.6.2 Transcription & Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-2-transcription-and-translation.md) - [2.6.3 End of Topic Test - DNA, Genes & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-3-end-of-topic-test-dna-genes-and-protein-synthesis.md) - [2.6.4 Exam-Style Question - Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-4-exam-style-question-protein-synthesis.md) - [2.6.5 End of Topic Test - Coronavirus Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-5-end-of-topic-test-coronavirus-translation.md) - [2.6.6 IB Multiple Choice - Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-6-ib-multiple-choice-transcription.md) - [2.6.7 IB Multiple Choice - Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-7-ib-multiple-choice-translation.md) - 2.7 Cell Respiration - [2.7.1 Overview of Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-1-overview-of-respiration.md) - [2.7.2 Anaerobic Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-2-anaerobic-respiration.md) - [2.7.3 End of Topic Test - Anaerobic Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-3-end-of-topic-test-anaerobic-respiration.md) - [2.7.4 Respiration Experiments](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-4-respiration-experiments.md) - [2.7.5 End of Topic Test - Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-5-end-of-topic-test-respiration.md) - [2.7.6 IB Multiple Choice - Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-6-ib-multiple-choice-respiration.md) - 2.8 Photosynthesis - [2.8.1 Overview of Photosynthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-8-1-overview-of-photosynthesis.md) - 2.9 Viruses - [2.9.1 Viruses](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-9-1-viruses.md) ### 3 Unity & Diversity - Organisms - 3.1 Diversity of Organisms - [3.1.1 Chromosomal Theory of Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-1-1-chromosomal-theory-of-inheritance.md) - [3.1.2 Chromosomal Basis of Inherited Disorders](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-1-2-chromosomal-basis-of-inherited-disorders.md) - [3.1.3 IB Multiple Choice - Chromosomal Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-1-3-ib-multiple-choice-chromosomal-inheritance.md) - 3.2 Evidence for Evolution - [3.2.1 Evidence for Evolution - Fossils & DNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-2-1-evidence-for-evolution-fossils-and-dna.md) - [3.2.2 Evidence for Evolution - Anatomy & Geography](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-2-2-evidence-for-evolution-anatomy-and-geography.md) - [3.2.3 IB Multiple Choice - Evidence for Evolution](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-2-3-ib-multiple-choice-evidence-for-evolution.md) - [3.2.4 Extended Response - DNA & Evolution](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-2-4-extended-response-dna-and-evolution.md) - 3.3 Natural Selection - [3.3.1 Introduction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-1-introduction.md) - [3.3.2 Evolutionary Fitness](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-2-evolutionary-fitness.md) - [3.3.3 Natural Selection & Variation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-3-natural-selection-and-variation.md) - [3.3.4 End of Topic Quiz - Natural Selection](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-4-end-of-topic-quiz-natural-selection.md) - [3.3.5 IB Multiple Choice - Natural Selection](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-5-ib-multiple-choice-natural-selection.md) - [3.3.6 Speciation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-6-speciation.md) ### 4 Unity & Diversity - Ecosystems - 4.1 Classification - [4.1.1 Introduction to Biodiversity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-1-1-introduction-to-biodiversity.md) - [4.1.2 Keystone Species](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-1-2-keystone-species.md) - [4.1.3 Courtship & Ancestry](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-1-3-courtship-and-ancestry.md) - [4.1.4 Classification](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-1-4-classification.md) - 4.2 Cladistics - [4.2.1 Evolutionary Relationships](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-2-1-evolutionary-relationships.md) - [4.2.2 IB Multiple Choice - Species & Taxonomy](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-2-2-ib-multiple-choice-species-and-taxonomy.md) - 4.3 Evolution & Speciation - [4.3.1 Evidence for Evolution - Fossils & DNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-1-evidence-for-evolution-fossils-and-dna.md) - [4.3.2 Evidence for Evolution - Anatomy & Geography](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-2-evidence-for-evolution-anatomy-and-geography.md) - [4.3.3 IB Multiple Choice - Evidence for Evolution](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-3-ib-multiple-choice-evidence-for-evolution.md) - [4.3.4 Extended Response - DNA & Evolution](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-4-extended-response-dna-and-evolution.md) - [4.3.5 Populations](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-5-populations.md) - [4.3.6 Mutations, Genetic Drift, & Gene Flow](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-6-mutations-genetic-drift-and-gene-flow.md) - [4.3.7 Speciation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-7-speciation.md) - [4.3.8 Rate of Speciation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-8-rate-of-speciation.md) - [4.3.9 Allopatric & Sympatric Speciation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-9-allopatric-and-sympatric-speciation.md) - 4.4 Conservation of Biodiversity - [4.4.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-4-1-coming-soon.md) ### 5 Form & Function - Molecules - 5.1 Carbohydrates & Lipids - [5.1.1 Monosaccharides](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-1-monosaccharides.md) - [5.1.2 Disaccharides & Polysaccharides](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-2-disaccharides-and-polysaccharides.md) - [5.1.3 Triglycerides & Phospholipids](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-3-triglycerides-and-phospholipids.md) - [5.1.4 Cellulose](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-4-cellulose.md) - [5.1.5 Starch & Glycogen](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-5-starch-and-glycogen.md) - 5.2 Proteins - [5.2.1 Structure & Functions of Proteins](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-2-1-structure-and-functions-of-proteins.md) ### 6 Form & Function - Cells - 6.1 Membranes & Membrane Transport - [6.1.1 Passive Movement Across Membranes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-1-1-passive-movement-across-membranes.md) - [6.1.2 Active Movement Across Membranes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-1-2-active-movement-across-membranes.md) - [6.1.3 Endocytosis & Exocystosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-1-3-endocytosis-and-exocystosis.md) - [6.1.4 Cell Membrane Structure & Permeability](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-1-4-cell-membrane-structure-and-permeability.md) - 6.2 Organelles & Compartmentalization - [6.2.1 Eukaryotic Cells & Organelles](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-2-1-eukaryotic-cells-and-organelles.md) - [6.2.2 Subcellular Components & Organelles](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-2-2-subcellular-components-and-organelles.md) - 6.3 Cell Specialization - [6.3.1 Cell Specialization](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-3-1-cell-specialization.md) ### 7 Form & Function - Organisms - 7.1 Gas Exchange - [7.1.1 Lung Structure & Alveoli](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-1-1-lung-structure-and-alveoli.md) - [7.1.2 Ventilation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-1-2-ventilation.md) - [7.1.3 Lung Disease](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-1-3-lung-disease.md) - [7.1.4 Lung Disease Data](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-1-4-lung-disease-data.md) - 7.2 Transport - [7.2.1 The Circulatory System](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-1-the-circulatory-system.md) - [7.2.2 The Heart](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-2-the-heart.md) - [7.2.3 Blood Vessels](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-3-blood-vessels.md) - [7.2.4 Cardiovascular Disease](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-4-cardiovascular-disease.md) - [7.2.5 Xylem Structure](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-5-xylem-structure.md) - [7.2.6 Cohesion-Tension Theory](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-6-cohesion-tension-theory.md) - [7.2.7 Investigating Transpiration Rate](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-7-investigating-transpiration-rate.md) - [7.2.8 Phloem Structure](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-8-phloem-structure.md) - [7.2.9 Translocation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-9-translocation.md) - 7.3 Muscle & Motility - [7.3.1 Skeletal Muscle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-3-1-skeletal-muscle.md) - [7.3.2 Sliding Filament Theory](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-3-2-sliding-filament-theory.md) - [7.3.3 Contraction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-3-3-contraction.md) ### 8 Form & Function - Ecosystems - 8.1 Species, Communities & Ecosytems - [8.1.1 Population Dynamics](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-1-population-dynamics.md) - [8.1.2 Communities & Measuring Diversity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-2-communities-and-measuring-diversity.md) - [8.1.3 Relationships Between Populations](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-3-relationships-between-populations.md) - [8.1.4 Overview of Ecosystems](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-4-overview-of-ecosystems.md) - [8.1.5 Nutrient Cycles](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-5-nutrient-cycles.md) - [8.1.6 Fertilisers](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-6-fertilisers.md) - [8.1.7 Eutrophication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-7-eutrophication.md) - [8.1.8 Chi-Squared Test](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-8-chi-squared-test.md) - 8.2 Energy Flow - [8.2.1 Energy](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-2-1-energy.md) - [8.2.2 Energy Flow](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-2-2-energy-flow.md) - [8.2.3 Biomass & Food Chains](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-2-3-biomass-and-food-chains.md) - [8.2.4 Heterotrophs & Autotrophs](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-2-4-heterotrophs-and-autotrophs.md) - 8.3 Carbon Cycle - [8.3.1 Carbon Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-3-1-carbon-cycle.md) - 8.4 Climate Change - [8.4.1 Carbon Dioxide](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-4-1-carbon-dioxide.md) - [8.4.2 The Greenhouse Effect](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-4-2-the-greenhouse-effect.md) - [8.4.3 Global Warming](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-4-3-global-warming.md) - [8.4.4 Maintaining Biodiversity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-4-4-maintaining-biodiversity.md) ### 9 Interaction & Interdependence - Molecules - 9.1 Enzymes - [9.1.1 Enzymes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-1-1-enzymes.md) - [9.1.2 Factors Affecting Enzyme Activity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-1-2-factors-affecting-enzyme-activity.md) - [9.1.3 Enzyme-Controlled Reactions](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-1-3-enzyme-controlled-reactions.md) - [9.1.4 End of Topic Test - Enzymes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-1-4-end-of-topic-test-enzymes.md) - 9.2 Metabolism - [9.2.1 Molecules to Metabolism](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-2-1-molecules-to-metabolism.md) - 9.3 Cell Respiration - [9.3.1 Glycolysis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-3-1-glycolysis.md) - [9.3.2 Aerobic Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-3-2-aerobic-respiration.md) - 9.4 Photosynthesis - [9.4.1 Light-Dependent Reaction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-1-light-dependent-reaction.md) - [9.4.2 Light-Independent Reaction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-2-light-independent-reaction.md) - [9.4.3 End of Topic Test - Photosynthesis Reactions](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-3-end-of-topic-test-photosynthesis-reactions.md) - [9.4.4 Limiting Factors](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-4-limiting-factors.md) - [9.4.5 Photosynthesis Experiments](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-5-photosynthesis-experiments.md) - [9.4.6 End of Topic Test - Photosynthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-6-end-of-topic-test-photosynthesis.md) - [9.4.7 End of Topic Test - Photosynthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-7-end-of-topic-test-photosynthesis.md) ### 10 Interaction & Interdependence - Cells - 10.1 Chemical Signalling - [10.1.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-1-1-coming-soon.md) - 10.2 Neural Signalling - [10.2.1 Medical Application](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-1-medical-application.md) - [10.2.2 Speed of Transmission](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-2-speed-of-transmission.md) - [10.2.3 Synapses](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-3-synapses.md) - [10.2.4 End of Topic Test - Nervous Comm&Coord](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-4-end-of-topic-test-nervous-commandcoord.md) - [10.2.5 Neuron Structure](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-5-neuron-structure.md) - [10.2.6 Types of Synapse](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-6-types-of-synapse.md) - [10.2.7 End of Topic Test - Neurones & Action Potentials](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-7-end-of-topic-test-neurones-and-action-potentials.md) - [10.2.8 Transmission of an Impulse](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-8-transmission-of-an-impulse.md) - [10.2.9 End of Topic Test - Synapses](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-9-end-of-topic-test-synapses.md) - 10.3 Adaptation to Environment - [10.3.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-3-1-coming-soon.md) - 10.4 Ecological Niches - [10.4.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-4-1-coming-soon.md) ### 11 Interaction & Interdependence - Organisms - 11.1 Integration of Body Systems - [11.1.1 Plant Tropisms](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-1-1-plant-tropisms.md) - 11.2 Defence Against Disease - [11.2.1 Immune System](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-1-immune-system.md) - [11.2.2 The Immune Response](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-2-the-immune-response.md) - [11.2.3 Antibodies](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-3-antibodies.md) - [11.2.4 Primary & Secondary Response](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-4-primary-and-secondary-response.md) - [11.2.5 Vaccines](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-5-vaccines.md) - [11.2.6 HIV](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-6-hiv.md) - [11.2.7 End of Topic Test - Immune System](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-7-end-of-topic-test-immune-system.md) ### 12 Interaction & Interdependence - Ecosystems - 12.1 Populations & Communities - [12.1.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/12-1-1-coming-soon.md) - 12.2 Transfers of Energy & Matter - [12.2.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/12-2-1-coming-soon.md) ### 13 Continuity & Change - Molecules - 13.1 DNA Replication - [13.1.1 DNA Replication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-1-1-dna-replication.md) - 13.2 Protein Synthesis - [13.2.1 Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-2-1-protein-synthesis.md) - [13.2.2 Transcription & Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-2-2-transcription-and-translation.md) - [13.2.3 End of Topic Test - DNA, Genes & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-2-3-end-of-topic-test-dna-genes-and-protein-synthesis.md) - 13.3 Mutation & Gene Editing - [13.3.1 Genes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-1-genes.md) - [13.3.2 Mutations](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-2-mutations.md) - [13.3.3 DNA Technology](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-3-dna-technology.md) - [13.3.4 PCR & Gel Electrophoresis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-4-pcr-and-gel-electrophoresis.md) - [13.3.5 Genetic Modification](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-5-genetic-modification.md) - [13.3.6 Cloning](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-6-cloning.md) ### 14 Continuity & Change - Cells - 14.1 Gene Expression - [14.1.1 Introduction to Transcription & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-1-introduction-to-transcription-and-protein-synthesis.md) - [14.1.2 Types of RNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-2-types-of-rna.md) - [14.1.3 Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-3-transcription.md) - [14.1.4 RNA Processing in Eukaryotes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-4-rna-processing-in-eukaryotes.md) - [14.1.5 IB Multiple Choice - Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-5-ib-multiple-choice-transcription.md) - 14.2 Water Potential - [14.2.1 Controlling Blood Water Potential](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-2-1-controlling-blood-water-potential.md) ### 15 Continuity & Change - Organisms - 15.1 Inheritance - [15.1.1 Non-Nuclear Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-1-non-nuclear-inheritance.md) - [15.1.2 Linked Genes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-2-linked-genes.md) - [15.1.3 IB Multiple Choice - Non-Mendelian Genetics](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-3-ib-multiple-choice-non-mendelian-genetics.md) - [15.1.4 Extended Response - Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-4-extended-response-inheritance.md) - [15.1.5 Introduction to Non-Mendelian Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-5-introduction-to-non-mendelian-inheritance.md) - [15.1.6 Chi-Squared Test](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-6-chi-squared-test.md) - [15.1.7 End of Topic Quiz - Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-7-end-of-topic-quiz-inheritance.md) - [15.1.8 Sex-Linked Genes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-8-sex-linked-genes.md) - [15.1.9 Grade 4-5 (Scientific Practices) - Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-9-grade-4-5-scientific-practices-inheritance.md) - 15.2 Homeostasis - [15.2.1 Overview of Homeostasis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-1-overview-of-homeostasis.md) - [15.2.2 Blood Glucose Concentration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-2-blood-glucose-concentration.md) - [15.2.3 Controlling Blood Glucose Concentration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-3-controlling-blood-glucose-concentration.md) - [15.2.4 End of Topic Test - Blood Glucose](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-4-end-of-topic-test-blood-glucose.md) - [15.2.5 Type I & Type II Diabetes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-5-type-i-and-type-ii-diabetes.md) - [15.2.6 Human Reproductive Systems](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-6-human-reproductive-systems.md) - [15.2.7 Hormonal Control of the Menstrual Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-7-hormonal-control-of-the-menstrual-cycle.md) - [15.2.8 Kidneys & Osmoregulation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-8-kidneys-and-osmoregulation.md) ### 16 Continuity & Change - Ecosystems - 16.1 Natural Selection - [16.1.1 Natural Selection](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-1-1-natural-selection.md) - 16.2 Stability & Change - [16.2.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-2-1-coming-soon.md) - 16.3 Climate Change - [16.3.1 Carbon Dioxide](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-3-1-carbon-dioxide.md) - [16.3.2 The Greenhouse Effect](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-3-2-the-greenhouse-effect.md) - [16.3.3 Global Warming](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-3-3-global-warming.md) - [16.3.4 Maintaining Biodiversity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-3-4-maintaining-biodiversity.md)