Source: https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-3-regulation-of-the-cell-cycle [Revision notes](https://senecalearning.com/en-gb/revision-notes.md) › [IB Diploma](https://senecalearning.com/en-gb/revision-notes/ib-diploma.md) › [Biology](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology.md) › [Biology: IB Diploma](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma.md) › Regulation of the Cell Cycle # Regulation of the Cell Cycle Biology: IB Diploma Higher Level, topic 2.4.3 ## Regulation of the Cell Cycle Each step of the cell cycle is closely monitored by external signals and internal controls called checkpoints. ### Regulation of the cell cycle ![Regulation of the cell cycle](https://image-v2.cdn.app.senecalearning.com/2018-09/e3c8609f-7236-42a4-a382-a937041982bf/stop-sign-.jpg) - Internal checkpoints are important in the regulation of the cell cycle. - Regulation of the cell cycle is particularly important as disruptions can lead to tumor development or apoptosis (programmed cell death). - There are three major checkpoints in the cell cycle: one near the end of G1, a second at the G2/M transition, and the third during metaphase. ### Checkpoints ![Checkpoints](https://image-v2.cdn.app.senecalearning.com/2019-03/087fa5a0-e7a3-4163-906f-7896f19b217e/magnifying-glass.jpeg) - At the first checkpoint (G1), DNA is checked to make sure there is no damage and the cell is checked to see if it is the correct size and has enough energy reserves. - At the second checkpoint (G2), chromosomes are checked to make sure that they have all been replicated and none of the duplicated DNA is faulty. - At the third checkpoint (M), sister chromatids are checked to confirm that their attachments to the spindle are suitable. ### Cell cycle regulators ![Cell cycle regulators](https://image-v2.cdn.app.senecalearning.com/2020-01/542b6e5f-6a6a-40fb-bbe0-4a50a0d0a764/Cyclins.png) - Two groups of proteins, called cyclins and cyclin-dependent kinases (Cdks), are responsible for the progress of the cell through the various checkpoints. - The levels of the four cyclin proteins fluctuate throughout the cell cycle in a predictable pattern. - Increases in the concentration of cyclin proteins are triggered by both external and internal signals. - After the cell moves to the next stage of the cell cycle, the cyclins that were active in the previous stage are degraded. ![](https://image-v2.cdn.app.senecalearning.com/2020-01/542b6e5f-6a6a-40fb-bbe0-4a50a0d0a764/Cyclins.png) ### Complexes ![Complexes](https://image-v2.cdn.app.senecalearning.com/2020-01/4424baba-a46d-496d-a752-770807247a2b/CDKs%20(1).png) - Cyclins regulate the cell cycle only when they are tightly bound to Cdks. - To be fully active, the Cdk/cyclin complex must also be phosphorylated in specific locations. - Phosphorylation activates the protein by changing its shape. - The proteins phosphorylated by Cdks are involved in advancing the cell to the next phase. - Different cyclins and Cdks bind at specific points in the cell cycle and thus regulate different checkpoints. ![](https://image-v2.cdn.app.senecalearning.com/2020-01/4424baba-a46d-496d-a752-770807247a2b/CDKs%20(1).png) ## Test yourself on Regulation of the Cell Cycle - How many checkpoints are involved in the regulation of the cell cycle? - Cyclins regulate the cell cycle only when they are tightly bound to which type of protein? [Practise this topic for free](https://app.senecalearning.com/classroom/course/549189f7-f13a-4c5c-b80c-ea1bd3036d78/section/1f673502-f13e-4817-89bc-709f690766d6/session) - Previous topic: [2.4.2 Mitosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-2-mitosis.md) - Next topic: [2.4.4 End of Topic Quiz - The Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-4-end-of-topic-quiz-the-cell-cycle.md) ## Biology: IB Diploma Higher Level contents ### 1 Unity & Diversity - Molecules - 1.1 Water - [1.1.1 The Importance of Water](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-1-the-importance-of-water.md) - [1.1.2 The Structure of Water](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-2-the-structure-of-water.md) - [1.1.3 The Properties of Water](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-3-the-properties-of-water.md) - [1.1.4 IB Multiple Choice - Water & Hydrogen Bonding](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-4-ib-multiple-choice-water-and-hydrogen-bonding.md) - [1.1.5 Extended Response - Water](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-1-5-extended-response-water.md) - 1.2 DNA Structure & Replication - [1.2.1 DNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-1-dna.md) - [1.2.2 RNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-2-rna.md) - [1.2.3 Semi-Conservative DNA Replication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-3-semi-conservative-dna-replication.md) - [1.2.4 DNA Replication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-4-dna-replication.md) - [1.2.5 DNA Replication - Summary](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-5-dna-replication-summary.md) - [1.2.6 IB Multiple Choice - DNA Replication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-2-6-ib-multiple-choice-dna-replication.md) - 1.3 Transcription & Gene Expression - [1.3.1 Introduction to Transcription & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-1-introduction-to-transcription-and-protein-synthesis.md) - [1.3.2 Types of RNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-2-types-of-rna.md) - [1.3.3 Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-3-transcription.md) - [1.3.4 RNA Processing in Eukaryotes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-4-rna-processing-in-eukaryotes.md) - [1.3.5 IB Multiple Choice - Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-3-5-ib-multiple-choice-transcription.md) - 1.4 Translation - [1.4.1 Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-4-1-translation.md) - [1.4.2 Retroviruses](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-4-2-retroviruses.md) - [1.4.3 Scientific Practices: Coronavirus](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-4-3-scientific-practices-coronavirus.md) - [1.4.4 IB Multiple Choice - Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/1-4-4-ib-multiple-choice-translation.md) ### 2 Unity & Diversity - Cells - 2.1 The Origin of Cells - [2.1.1 Origins - Endosymbiosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-1-1-origins-endosymbiosis.md) - 2.2 Introduction to Cells - [2.2.1 Introduction to Cells](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-1-introduction-to-cells.md) - [2.2.2 Cell Size & Surface Area](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-2-cell-size-and-surface-area.md) - [2.2.3 Surface Area to Volume Ratio](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-3-surface-area-to-volume-ratio.md) - [2.2.4 Eukaryotic vs Prokaryotic Cells](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-4-eukaryotic-vs-prokaryotic-cells.md) - [2.2.5 Stem Cells](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-5-stem-cells.md) - [2.2.6 Stem Cells in Disease](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-2-6-stem-cells-in-disease.md) - 2.3 Ultrastructure of Cells - [2.3.1 Golgi, Lysosomes & Ribosomes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-3-1-golgi-lysosomes-and-ribosomes.md) - [2.3.2 Cell Walls & Vacuole](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-3-2-cell-walls-and-vacuole.md) - [2.3.3 Prokaryotes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-3-3-prokaryotes.md) - [2.3.4 Binary Fission](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-3-4-binary-fission.md) - 2.4 Cell Division - [2.4.1 The Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-1-the-cell-cycle.md) - [2.4.2 Mitosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-2-mitosis.md) - [2.4.3 Regulation of the Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-3-regulation-of-the-cell-cycle.md) - [2.4.4 End of Topic Quiz - The Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-4-end-of-topic-quiz-the-cell-cycle.md) - [2.4.5 IB Multiple Choice - The Cell Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-5-ib-multiple-choice-the-cell-cycle.md) - [2.4.6 Extended Response - Mitosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-4-6-extended-response-mitosis.md) - 2.5 Structure of DNA & RNA - [2.5.1 DNA & RNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-5-1-dna-and-rna.md) - 2.6 DNA Replication, Transcription & Translation - [2.6.1 Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-1-protein-synthesis.md) - [2.6.2 Transcription & Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-2-transcription-and-translation.md) - [2.6.3 End of Topic Test - DNA, Genes & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-3-end-of-topic-test-dna-genes-and-protein-synthesis.md) - [2.6.4 Exam-Style Question - Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-4-exam-style-question-protein-synthesis.md) - [2.6.5 End of Topic Test - Coronavirus Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-5-end-of-topic-test-coronavirus-translation.md) - [2.6.6 IB Multiple Choice - Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-6-ib-multiple-choice-transcription.md) - [2.6.7 IB Multiple Choice - Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-6-7-ib-multiple-choice-translation.md) - 2.7 Cell Respiration - [2.7.1 Overview of Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-1-overview-of-respiration.md) - [2.7.2 Anaerobic Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-2-anaerobic-respiration.md) - [2.7.3 End of Topic Test - Anaerobic Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-3-end-of-topic-test-anaerobic-respiration.md) - [2.7.4 Respiration Experiments](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-4-respiration-experiments.md) - [2.7.5 End of Topic Test - Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-5-end-of-topic-test-respiration.md) - [2.7.6 IB Multiple Choice - Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-7-6-ib-multiple-choice-respiration.md) - 2.8 Photosynthesis - [2.8.1 Overview of Photosynthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-8-1-overview-of-photosynthesis.md) - 2.9 Viruses - [2.9.1 Viruses](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/2-9-1-viruses.md) ### 3 Unity & Diversity - Organisms - 3.1 Diversity of Organisms - [3.1.1 Chromosomal Theory of Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-1-1-chromosomal-theory-of-inheritance.md) - [3.1.2 Chromosomal Basis of Inherited Disorders](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-1-2-chromosomal-basis-of-inherited-disorders.md) - [3.1.3 IB Multiple Choice - Chromosomal Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-1-3-ib-multiple-choice-chromosomal-inheritance.md) - 3.2 Evidence for Evolution - [3.2.1 Evidence for Evolution - Fossils & DNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-2-1-evidence-for-evolution-fossils-and-dna.md) - [3.2.2 Evidence for Evolution - Anatomy & Geography](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-2-2-evidence-for-evolution-anatomy-and-geography.md) - [3.2.3 IB Multiple Choice - Evidence for Evolution](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-2-3-ib-multiple-choice-evidence-for-evolution.md) - [3.2.4 Extended Response - DNA & Evolution](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-2-4-extended-response-dna-and-evolution.md) - 3.3 Natural Selection - [3.3.1 Introduction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-1-introduction.md) - [3.3.2 Evolutionary Fitness](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-2-evolutionary-fitness.md) - [3.3.3 Natural Selection & Variation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-3-natural-selection-and-variation.md) - [3.3.4 End of Topic Quiz - Natural Selection](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-4-end-of-topic-quiz-natural-selection.md) - [3.3.5 IB Multiple Choice - Natural Selection](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-5-ib-multiple-choice-natural-selection.md) - [3.3.6 Speciation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/3-3-6-speciation.md) ### 4 Unity & Diversity - Ecosystems - 4.1 Classification - [4.1.1 Introduction to Biodiversity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-1-1-introduction-to-biodiversity.md) - [4.1.2 Keystone Species](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-1-2-keystone-species.md) - [4.1.3 Courtship & Ancestry](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-1-3-courtship-and-ancestry.md) - [4.1.4 Classification](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-1-4-classification.md) - 4.2 Cladistics - [4.2.1 Evolutionary Relationships](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-2-1-evolutionary-relationships.md) - [4.2.2 IB Multiple Choice - Species & Taxonomy](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-2-2-ib-multiple-choice-species-and-taxonomy.md) - 4.3 Evolution & Speciation - [4.3.1 Evidence for Evolution - Fossils & DNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-1-evidence-for-evolution-fossils-and-dna.md) - [4.3.2 Evidence for Evolution - Anatomy & Geography](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-2-evidence-for-evolution-anatomy-and-geography.md) - [4.3.3 IB Multiple Choice - Evidence for Evolution](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-3-ib-multiple-choice-evidence-for-evolution.md) - [4.3.4 Extended Response - DNA & Evolution](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-4-extended-response-dna-and-evolution.md) - [4.3.5 Populations](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-5-populations.md) - [4.3.6 Mutations, Genetic Drift, & Gene Flow](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-6-mutations-genetic-drift-and-gene-flow.md) - [4.3.7 Speciation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-7-speciation.md) - [4.3.8 Rate of Speciation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-8-rate-of-speciation.md) - [4.3.9 Allopatric & Sympatric Speciation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-3-9-allopatric-and-sympatric-speciation.md) - 4.4 Conservation of Biodiversity - [4.4.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/4-4-1-coming-soon.md) ### 5 Form & Function - Molecules - 5.1 Carbohydrates & Lipids - [5.1.1 Monosaccharides](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-1-monosaccharides.md) - [5.1.2 Disaccharides & Polysaccharides](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-2-disaccharides-and-polysaccharides.md) - [5.1.3 Triglycerides & Phospholipids](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-3-triglycerides-and-phospholipids.md) - [5.1.4 Cellulose](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-4-cellulose.md) - [5.1.5 Starch & Glycogen](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-1-5-starch-and-glycogen.md) - 5.2 Proteins - [5.2.1 Structure & Functions of Proteins](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/5-2-1-structure-and-functions-of-proteins.md) ### 6 Form & Function - Cells - 6.1 Membranes & Membrane Transport - [6.1.1 Passive Movement Across Membranes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-1-1-passive-movement-across-membranes.md) - [6.1.2 Active Movement Across Membranes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-1-2-active-movement-across-membranes.md) - [6.1.3 Endocytosis & Exocystosis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-1-3-endocytosis-and-exocystosis.md) - [6.1.4 Cell Membrane Structure & Permeability](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-1-4-cell-membrane-structure-and-permeability.md) - 6.2 Organelles & Compartmentalization - [6.2.1 Eukaryotic Cells & Organelles](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-2-1-eukaryotic-cells-and-organelles.md) - [6.2.2 Subcellular Components & Organelles](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-2-2-subcellular-components-and-organelles.md) - 6.3 Cell Specialization - [6.3.1 Cell Specialization](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/6-3-1-cell-specialization.md) ### 7 Form & Function - Organisms - 7.1 Gas Exchange - [7.1.1 Lung Structure & Alveoli](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-1-1-lung-structure-and-alveoli.md) - [7.1.2 Ventilation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-1-2-ventilation.md) - [7.1.3 Lung Disease](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-1-3-lung-disease.md) - [7.1.4 Lung Disease Data](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-1-4-lung-disease-data.md) - 7.2 Transport - [7.2.1 The Circulatory System](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-1-the-circulatory-system.md) - [7.2.2 The Heart](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-2-the-heart.md) - [7.2.3 Blood Vessels](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-3-blood-vessels.md) - [7.2.4 Cardiovascular Disease](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-4-cardiovascular-disease.md) - [7.2.5 Xylem Structure](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-5-xylem-structure.md) - [7.2.6 Cohesion-Tension Theory](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-6-cohesion-tension-theory.md) - [7.2.7 Investigating Transpiration Rate](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-7-investigating-transpiration-rate.md) - [7.2.8 Phloem Structure](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-8-phloem-structure.md) - [7.2.9 Translocation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-2-9-translocation.md) - 7.3 Muscle & Motility - [7.3.1 Skeletal Muscle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-3-1-skeletal-muscle.md) - [7.3.2 Sliding Filament Theory](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-3-2-sliding-filament-theory.md) - [7.3.3 Contraction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/7-3-3-contraction.md) ### 8 Form & Function - Ecosystems - 8.1 Species, Communities & Ecosytems - [8.1.1 Population Dynamics](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-1-population-dynamics.md) - [8.1.2 Communities & Measuring Diversity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-2-communities-and-measuring-diversity.md) - [8.1.3 Relationships Between Populations](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-3-relationships-between-populations.md) - [8.1.4 Overview of Ecosystems](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-4-overview-of-ecosystems.md) - [8.1.5 Nutrient Cycles](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-5-nutrient-cycles.md) - [8.1.6 Fertilisers](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-6-fertilisers.md) - [8.1.7 Eutrophication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-7-eutrophication.md) - [8.1.8 Chi-Squared Test](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-1-8-chi-squared-test.md) - 8.2 Energy Flow - [8.2.1 Energy](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-2-1-energy.md) - [8.2.2 Energy Flow](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-2-2-energy-flow.md) - [8.2.3 Biomass & Food Chains](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-2-3-biomass-and-food-chains.md) - [8.2.4 Heterotrophs & Autotrophs](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-2-4-heterotrophs-and-autotrophs.md) - 8.3 Carbon Cycle - [8.3.1 Carbon Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-3-1-carbon-cycle.md) - 8.4 Climate Change - [8.4.1 Carbon Dioxide](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-4-1-carbon-dioxide.md) - [8.4.2 The Greenhouse Effect](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-4-2-the-greenhouse-effect.md) - [8.4.3 Global Warming](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-4-3-global-warming.md) - [8.4.4 Maintaining Biodiversity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/8-4-4-maintaining-biodiversity.md) ### 9 Interaction & Interdependence - Molecules - 9.1 Enzymes - [9.1.1 Enzymes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-1-1-enzymes.md) - [9.1.2 Factors Affecting Enzyme Activity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-1-2-factors-affecting-enzyme-activity.md) - [9.1.3 Enzyme-Controlled Reactions](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-1-3-enzyme-controlled-reactions.md) - [9.1.4 End of Topic Test - Enzymes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-1-4-end-of-topic-test-enzymes.md) - 9.2 Metabolism - [9.2.1 Molecules to Metabolism](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-2-1-molecules-to-metabolism.md) - 9.3 Cell Respiration - [9.3.1 Glycolysis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-3-1-glycolysis.md) - [9.3.2 Aerobic Respiration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-3-2-aerobic-respiration.md) - 9.4 Photosynthesis - [9.4.1 Light-Dependent Reaction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-1-light-dependent-reaction.md) - [9.4.2 Light-Independent Reaction](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-2-light-independent-reaction.md) - [9.4.3 End of Topic Test - Photosynthesis Reactions](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-3-end-of-topic-test-photosynthesis-reactions.md) - [9.4.4 Limiting Factors](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-4-limiting-factors.md) - [9.4.5 Photosynthesis Experiments](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-5-photosynthesis-experiments.md) - [9.4.6 End of Topic Test - Photosynthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-6-end-of-topic-test-photosynthesis.md) - [9.4.7 End of Topic Test - Photosynthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/9-4-7-end-of-topic-test-photosynthesis.md) ### 10 Interaction & Interdependence - Cells - 10.1 Chemical Signalling - [10.1.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-1-1-coming-soon.md) - 10.2 Neural Signalling - [10.2.1 Medical Application](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-1-medical-application.md) - [10.2.2 Speed of Transmission](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-2-speed-of-transmission.md) - [10.2.3 Synapses](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-3-synapses.md) - [10.2.4 End of Topic Test - Nervous Comm&Coord](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-4-end-of-topic-test-nervous-commandcoord.md) - [10.2.5 Neuron Structure](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-5-neuron-structure.md) - [10.2.6 Types of Synapse](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-6-types-of-synapse.md) - [10.2.7 End of Topic Test - Neurones & Action Potentials](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-7-end-of-topic-test-neurones-and-action-potentials.md) - [10.2.8 Transmission of an Impulse](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-8-transmission-of-an-impulse.md) - [10.2.9 End of Topic Test - Synapses](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-2-9-end-of-topic-test-synapses.md) - 10.3 Adaptation to Environment - [10.3.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-3-1-coming-soon.md) - 10.4 Ecological Niches - [10.4.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/10-4-1-coming-soon.md) ### 11 Interaction & Interdependence - Organisms - 11.1 Integration of Body Systems - [11.1.1 Plant Tropisms](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-1-1-plant-tropisms.md) - 11.2 Defence Against Disease - [11.2.1 Immune System](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-1-immune-system.md) - [11.2.2 The Immune Response](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-2-the-immune-response.md) - [11.2.3 Antibodies](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-3-antibodies.md) - [11.2.4 Primary & Secondary Response](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-4-primary-and-secondary-response.md) - [11.2.5 Vaccines](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-5-vaccines.md) - [11.2.6 HIV](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-6-hiv.md) - [11.2.7 End of Topic Test - Immune System](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/11-2-7-end-of-topic-test-immune-system.md) ### 12 Interaction & Interdependence - Ecosystems - 12.1 Populations & Communities - [12.1.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/12-1-1-coming-soon.md) - 12.2 Transfers of Energy & Matter - [12.2.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/12-2-1-coming-soon.md) ### 13 Continuity & Change - Molecules - 13.1 DNA Replication - [13.1.1 DNA Replication](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-1-1-dna-replication.md) - 13.2 Protein Synthesis - [13.2.1 Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-2-1-protein-synthesis.md) - [13.2.2 Transcription & Translation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-2-2-transcription-and-translation.md) - [13.2.3 End of Topic Test - DNA, Genes & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-2-3-end-of-topic-test-dna-genes-and-protein-synthesis.md) - 13.3 Mutation & Gene Editing - [13.3.1 Genes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-1-genes.md) - [13.3.2 Mutations](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-2-mutations.md) - [13.3.3 DNA Technology](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-3-dna-technology.md) - [13.3.4 PCR & Gel Electrophoresis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-4-pcr-and-gel-electrophoresis.md) - [13.3.5 Genetic Modification](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-5-genetic-modification.md) - [13.3.6 Cloning](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/13-3-6-cloning.md) ### 14 Continuity & Change - Cells - 14.1 Gene Expression - [14.1.1 Introduction to Transcription & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-1-introduction-to-transcription-and-protein-synthesis.md) - [14.1.2 Types of RNA](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-2-types-of-rna.md) - [14.1.3 Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-3-transcription.md) - [14.1.4 RNA Processing in Eukaryotes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-4-rna-processing-in-eukaryotes.md) - [14.1.5 IB Multiple Choice - Transcription](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-1-5-ib-multiple-choice-transcription.md) - 14.2 Water Potential - [14.2.1 Controlling Blood Water Potential](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/14-2-1-controlling-blood-water-potential.md) ### 15 Continuity & Change - Organisms - 15.1 Inheritance - [15.1.1 Non-Nuclear Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-1-non-nuclear-inheritance.md) - [15.1.2 Linked Genes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-2-linked-genes.md) - [15.1.3 IB Multiple Choice - Non-Mendelian Genetics](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-3-ib-multiple-choice-non-mendelian-genetics.md) - [15.1.4 Extended Response - Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-4-extended-response-inheritance.md) - [15.1.5 Introduction to Non-Mendelian Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-5-introduction-to-non-mendelian-inheritance.md) - [15.1.6 Chi-Squared Test](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-6-chi-squared-test.md) - [15.1.7 End of Topic Quiz - Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-7-end-of-topic-quiz-inheritance.md) - [15.1.8 Sex-Linked Genes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-8-sex-linked-genes.md) - [15.1.9 Grade 4-5 (Scientific Practices) - Inheritance](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-1-9-grade-4-5-scientific-practices-inheritance.md) - 15.2 Homeostasis - [15.2.1 Overview of Homeostasis](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-1-overview-of-homeostasis.md) - [15.2.2 Blood Glucose Concentration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-2-blood-glucose-concentration.md) - [15.2.3 Controlling Blood Glucose Concentration](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-3-controlling-blood-glucose-concentration.md) - [15.2.4 End of Topic Test - Blood Glucose](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-4-end-of-topic-test-blood-glucose.md) - [15.2.5 Type I & Type II Diabetes](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-5-type-i-and-type-ii-diabetes.md) - [15.2.6 Human Reproductive Systems](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-6-human-reproductive-systems.md) - [15.2.7 Hormonal Control of the Menstrual Cycle](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-7-hormonal-control-of-the-menstrual-cycle.md) - [15.2.8 Kidneys & Osmoregulation](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/15-2-8-kidneys-and-osmoregulation.md) ### 16 Continuity & Change - Ecosystems - 16.1 Natural Selection - [16.1.1 Natural Selection](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-1-1-natural-selection.md) - 16.2 Stability & Change - [16.2.1 Coming Soon!](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-2-1-coming-soon.md) - 16.3 Climate Change - [16.3.1 Carbon Dioxide](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-3-1-carbon-dioxide.md) - [16.3.2 The Greenhouse Effect](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-3-2-the-greenhouse-effect.md) - [16.3.3 Global Warming](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-3-3-global-warming.md) - [16.3.4 Maintaining Biodiversity](https://senecalearning.com/en-gb/revision-notes/ib-diploma/biology/biology-ib-diploma/16-3-4-maintaining-biodiversity.md)