Source: https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-4-dna-replication [Revision notes](https://senecalearning.com/en-gb/revision-notes.md) › [A Level](https://senecalearning.com/en-gb/revision-notes/a-level.md) › [Biology](https://senecalearning.com/en-gb/revision-notes/a-level/biology.md) › [AQA](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa.md) › DNA Replication # DNA Replication Biology: AQA A Level, topic 1.5.4 ## DNA Replication When a cell divides, it forms two daughter cells. This means that before cell division, the cell must duplicate its DNA so that each daughter cell can inherit the full set of DNA. ### DNA replication ![DNA replication](https://image-v2.cdn.app.senecalearning.com/2018-08/510ae477-721b-4c90-9838-c6ee65b41916/DNA%20Polymerase.jpg) - DNA is made up of two polynucleotide strands that form a double helix. - During DNA replication, each of the two strands are used as a template from which new strands are copied. ### Semi-conservative model ![Semi-conservative model](https://image-v2.cdn.app.senecalearning.com/2018-09/c73a7967-270c-442f-a95b-d4ebb4995234/Meselson-Stahl-dna-replication-semi-conervative-nitrogen-.png) - After replication, the new DNA is made up of one original polynucleotide strand and a new, complementary strand. - This explains why DNA replication is described as semi-conservative because one original strand is conserved. ### The process of replication (1) ![The process of replication (1)](https://image-v2.cdn.app.senecalearning.com/2018-08/9bd44e8a-baaa-4fd2-badf-3116a2573ff3/Helicase%20Action.jpg) - DNA helicase binds to DNA and breaks the hydrogen bonds between the two strands. - The DNA helix unwinds and the two strands separate. ### The process of replication (2) ![The process of replication (2)](https://image-v2.cdn.app.senecalearning.com/2018-08/ff2107a9-094f-48bd-bca2-2a141dfa4308/Complementary%20Base%20Pairing.jpg) - Free-floating nucleotides form hydrogen bonds with the complementary bases. - Each strand is used as a template to produce complementary strands. ### The process of replication (3) ![The process of replication (3)](https://image-v2.cdn.app.senecalearning.com/2018-08/131ffeb7-d1e6-4532-9d63-e449ec712b1d/DNA%20Polymerase.jpg) - DNA polymerase forms phosphodiester bonds between the nucleotides. - Two new DNA strands are synthesised. ## Strands of the Double Helix Nucleotides join together to form a polynucleotide strand. Two polynucleotide strands coil together to form a double helix. ### DNA strands ![DNA strands](https://image-v2.cdn.app.senecalearning.com/courseImages/biology/6.1.3%20DNA%20chemical%20structure.png) - The carbon atoms of the sugar molecule are numbered as 1′, 2′, 3′, 4′, and 5′ (1′ is read as “one prime”). - The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide. - The bond is called a 5′–3′ phosphodiester linkage. ### Antiparallel ![Antiparallel](https://image-v2.cdn.app.senecalearning.com/courseImages/biology/6.1.2%20-%20DNA/dna-163466_640-min.jpg) - This is called an antiparallel orientation because the helix's two strands run in opposite directions. - The 5′ carbon end of one strand will face the 3′ carbon end of its matching strand. ### DNA polymerase ![DNA polymerase](https://image-v2.cdn.app.senecalearning.com/2018-08/dbb07e9e-4735-4d88-8fe3-75411064ad9c/DNA%20Polymerase.jpg) - DNA polymerase catalyses the condensation reaction between the nucleotides in a DNA strand. - DNA polymerase forms phosphodiester bonds between adjacent nucleotides. ## Models of DNA Replication It is important to understand how the discoveries of Watson and Crick, and later Meselson and Stahl, confirm the semi-conservative replication hypothesis of DNA replication. ### Watson and Crick ![Watson and Crick](https://image-v2.cdn.app.senecalearning.com/courseImages/biology/6.1.2%20-%20DNA/DNA%20base%20structure%20(1)%20-%20Edited%20(1)-min.png) - In 1953, two scientists called Watson and Crick found that specific base pairing was involved in a way of copying sequences of genetic information. - They thought that each strand acts as a template from which the new complementary strand is copied. - But they didn't know how replication took place. - They proposed three models of replication including conservative replication. ### Meselson and Stahl ![Meselson and Stahl](https://image-v2.cdn.app.senecalearning.com/2018-09/c73a7967-270c-442f-a95b-d4ebb4995234/Meselson-Stahl-dna-replication-semi-conervative-nitrogen-.png) - Meselson and Stahl were interested in understanding how DNA replicates. - They grew E. coli for several generations in one medium containing a “heavy” isotope of nitrogen (15N) and another medium containing a 'light' isotope of nitrogen (14N). - During replication, the nitrogen gets included into nitrogenous bases, and eventually into the DNA. ### Isolating DNA ![Isolating DNA](https://image-v2.cdn.app.senecalearning.com/2018-09/c73a7967-270c-442f-a95b-d4ebb4995234/Meselson-Stahl-dna-replication-semi-conervative-nitrogen-.png) - After each of the first few generations, the cells were harvested and the DNA was isolated, then centrifuged. - The DNA formed separate bands according to its density. DNA grown in "heavy" 15N formed a band lower down the centrifuge tube than that grown in "light" 14N. ### The middle band ![The middle band](https://image-v2.cdn.app.senecalearning.com/2018-09/c73a7967-270c-442f-a95b-d4ebb4995234/Meselson-Stahl-dna-replication-semi-conervative-nitrogen-.png) - Meselson and Stahl moved E. coli from the 15N batch to a broth containing 14N only. - They noted that after one generation of growth in 14N, the single band observed was in the space between DNA of cells grown exclusively in 15N and 14N. - This suggested a semi-conservative mode of replication. ### Conclusive evidence ![Conclusive evidence](https://image-v2.cdn.app.senecalearning.com/2018-09/c73a7967-270c-442f-a95b-d4ebb4995234/Meselson-Stahl-dna-replication-semi-conervative-nitrogen-.png) - The DNA harvested from cells grown for two generations in 14N formed two bands: - One DNA band was between 15N and 14N. - The other DNA band corresponded to the band of 14N DNA. - These results could only be explained if DNA replicates in a semi-conservative manner. ## Test yourself on DNA Replication - What is true of new DNA strands formed during replication? - Which of the following statements about semi-conservative replication are true? - Which enzyme separates the two strands of DNA? - What is the name given to the orientation of DNA strands in the double helix? - Which of the following statements about DNA polymerase are true? [Practise this topic for free](https://app.senecalearning.com/classroom/course/d0ce0c30-6417-11e8-8edc-d9cd1c890408/section/34e96dcf-30ae-4bb7-aac1-52b01c918f4b/session) - Previous topic: [1.5.3 Polynucleotides](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-3-polynucleotides.md) - Next topic: [1.5.5 Exam-Style Question - Nucleic Acids](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-5-exam-style-question-nucleic-acids.md) ## Biology: AQA A Level contents ### 1 Biological Molecules - 1.1 Monomers & Polymers - [1.1.1 Monomers & Polymers](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-1-1-monomers-and-polymers.md) - [1.1.2 Condensation & Hydrolysis Reactions](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-1-2-condensation-and-hydrolysis-reactions.md) - 1.2 Carbohydrates - [1.2.1 Structure of Carbohydrates](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-2-1-structure-of-carbohydrates.md) - [1.2.2 Types of Polysaccharides](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-2-2-types-of-polysaccharides.md) - [1.2.3 End of Topic Test - Monomers, Polymers and Carbs](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-2-3-end-of-topic-test-monomers-polymers-and-carbs.md) - [1.2.4 Exam-Style Question - Carbohydrates](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-2-4-exam-style-question-carbohydrates.md) - [1.2.5 A-A* (AO3/4) - Carbohydrates](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-2-5-a-a-ao34-carbohydrates.md) - 1.3 Lipids - [1.3.1 Triglycerides & Phospholipids](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-3-1-triglycerides-and-phospholipids.md) - [1.3.2 Types of Fatty Acids](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-3-2-types-of-fatty-acids.md) - [1.3.3 Testing for Lipids](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-3-3-testing-for-lipids.md) - [1.3.4 Exam-Style Question - Fats](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-3-4-exam-style-question-fats.md) - [1.3.5 A-A* (AO3/4) - Lipids](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-3-5-a-a-ao34-lipids.md) - 1.4 Proteins - [1.4.1 The Peptide Chain](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-1-the-peptide-chain.md) - [1.4.2 Investigating Proteins](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-2-investigating-proteins.md) - [1.4.3 Primary & Secondary Protein Structure](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-3-primary-and-secondary-protein-structure.md) - [1.4.4 Tertiary & Quaternary Protein Structure](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-4-tertiary-and-quaternary-protein-structure.md) - [1.4.5 Enzymes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-5-enzymes.md) - [1.4.6 Factors Affecting Enzyme Activity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-6-factors-affecting-enzyme-activity.md) - [1.4.7 Enzyme-Controlled Reactions](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-7-enzyme-controlled-reactions.md) - [1.4.8 End of Topic Test - Lipids & Proteins](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-8-end-of-topic-test-lipids-and-proteins.md) - [1.4.9 A-A* (AO3/4) - Enzymes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-9-a-a-ao34-enzymes.md) - [1.4.10 A-A* (AO3/4) - Proteins](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-10-a-a-ao34-proteins.md) - [1.4.11 Diagnostic Misconceptions - Enzyme Inhibitors](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-4-11-diagnostic-misconceptions-enzyme-inhibitors.md) - 1.5 Nucleic Acids - [1.5.1 DNA & RNA](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-1-dna-and-rna.md) - [1.5.2 Nucleotides](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-2-nucleotides.md) - [1.5.3 Polynucleotides](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-3-polynucleotides.md) - [1.5.4 DNA Replication](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-4-dna-replication.md) - [1.5.5 Exam-Style Question - Nucleic Acids](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-5-exam-style-question-nucleic-acids.md) - [1.5.6 A-A* (AO3/4) - Nucleic Acids](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-5-6-a-a-ao34-nucleic-acids.md) - 1.6 ATP - [1.6.1 Structure of ATP](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-6-1-structure-of-atp.md) - [1.6.2 Hydrolysis of ATP](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-6-2-hydrolysis-of-atp.md) - [1.6.3 Resynthesis of ATP](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-6-3-resynthesis-of-atp.md) - [1.6.4 End of Topic Test - Nucleic Acids & ATP](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-6-4-end-of-topic-test-nucleic-acids-and-atp.md) - 1.7 Water - [1.7.1 Importance of Water](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-7-1-importance-of-water.md) - [1.7.2 Structure of Water](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-7-2-structure-of-water.md) - [1.7.3 Properties of Water](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-7-3-properties-of-water.md) - [1.7.4 A-A* (AO3/4) - Water](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-7-4-a-a-ao34-water.md) - 1.8 Inorganic Ions - [1.8.1 Inorganic Ions](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-8-1-inorganic-ions.md) - [1.8.2 End of Topic Test - Water & Inorganic Ions](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/1-8-2-end-of-topic-test-water-and-inorganic-ions.md) ### 2 Cells - 2.1 Cell Structure - [2.1.1 Introduction to Cells](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-1-introduction-to-cells.md) - [2.1.2 Eukaryotic Cells & Organelles](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-2-eukaryotic-cells-and-organelles.md) - [2.1.3 Eukaryotic Cells & Organelles 2](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-3-eukaryotic-cells-and-organelles-2.md) - [2.1.4 Prokaryotes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-4-prokaryotes.md) - [2.1.5 A-A* (AO3/4) - Organelles](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-5-a-a-ao34-organelles.md) - [2.1.6 Methods of Studying Cells](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-6-methods-of-studying-cells.md) - [2.1.7 Microscopes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-7-microscopes.md) - [2.1.8 End of Topic Test - Cell Structure](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-8-end-of-topic-test-cell-structure.md) - [2.1.9 Exam-Style Question - Cells](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-9-exam-style-question-cells.md) - [2.1.10 A-A* (AO3/4) - Cells](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-1-10-a-a-ao34-cells.md) - 2.2 Mitosis & Cancer - [2.2.1 Mitosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-2-1-mitosis.md) - [2.2.2 Stages of Mitosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-2-2-stages-of-mitosis.md) - [2.2.3 Investigating Mitosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-2-3-investigating-mitosis.md) - [2.2.4 Cancer](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-2-4-cancer.md) - [2.2.5 A-A* (AO3/4) - The Cell Cycle](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-2-5-a-a-ao34-the-cell-cycle.md) - 2.3 Transport Across Cell Membrane - [2.3.1 Cell Membrane Structure](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-1-cell-membrane-structure.md) - [2.3.2 A-A* (AO3/4) - Membrane Structure](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-2-a-a-ao34-membrane-structure.md) - [2.3.3 Diffusion](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-3-diffusion.md) - [2.3.4 Osmosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-4-osmosis.md) - [2.3.5 Active Transport](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-5-active-transport.md) - [2.3.6 End of Topic Test - Mitosis, Cancer & Transport](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-6-end-of-topic-test-mitosis-cancer-and-transport.md) - [2.3.7 Exam-Style Question - Membranes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-7-exam-style-question-membranes.md) - [2.3.8 A-A* (AO3/4) - Membranes & Transport](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-8-a-a-ao34-membranes-and-transport.md) - [2.3.9 A-A*- Mitosis, Cancer & Transport](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-3-9-a-a-mitosis-cancer-and-transport.md) - 2.4 Cell Recognition & the Immune System - [2.4.1 Immune System](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-1-immune-system.md) - [2.4.2 Phagocytosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-2-phagocytosis.md) - [2.4.3 T Lymphocytes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-3-t-lymphocytes.md) - [2.4.4 B Lymphocytes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-4-b-lymphocytes.md) - [2.4.5 Antibodies](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-5-antibodies.md) - [2.4.6 Primary & Secondary Response](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-6-primary-and-secondary-response.md) - [2.4.7 Vaccines](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-7-vaccines.md) - [2.4.8 HIV](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-8-hiv.md) - [2.4.9 Ethical Issues](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-9-ethical-issues.md) - [2.4.10 End of Topic Test - Immune System](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-10-end-of-topic-test-immune-system.md) - [2.4.11 Exam-Style Question - Immune System](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-11-exam-style-question-immune-system.md) - [2.4.12 A-A* (AO3/4) - Immune System](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-12-a-a-ao34-immune-system.md) - [2.4.13 Diagnostic Misconceptions - Humoral vs Cellular](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/2-4-13-diagnostic-misconceptions-humoral-vs-cellular.md) ### 3 Substance Exchange - 3.1 Surface Area to Volume Ratio - [3.1.1 Size & Surface Area](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-1-1-size-and-surface-area.md) - [3.1.2 A-A* (AO3/4) - Cell Size](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-1-2-a-a-ao34-cell-size.md) - 3.2 Gas Exchange - [3.2.1 Single-Celled Organisms](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-1-single-celled-organisms.md) - [3.2.2 Multicellular Organisms](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-2-multicellular-organisms.md) - [3.2.3 Control of Water Loss](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-3-control-of-water-loss.md) - [3.2.4 Human Gas Exchange](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-4-human-gas-exchange.md) - [3.2.5 Ventilation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-5-ventilation.md) - [3.2.6 Dissection](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-6-dissection.md) - [3.2.7 Measuring Gas Exchange](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-7-measuring-gas-exchange.md) - [3.2.8 Lung Disease](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-8-lung-disease.md) - [3.2.9 Lung Disease Data](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-9-lung-disease-data.md) - [3.2.10 End of Topic Test - Gas Exchange](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-10-end-of-topic-test-gas-exchange.md) - [3.2.11 A-A* (AO3/4) - Gas Exchange](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-2-11-a-a-ao34-gas-exchange.md) - 3.3 Digestion & Absorption - [3.3.1 Overview of Digestion](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-3-1-overview-of-digestion.md) - [3.3.2 Digestion in Mammals](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-3-2-digestion-in-mammals.md) - [3.3.3 Absorption](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-3-3-absorption.md) - [3.3.4 End of Topic Test - Substance Exchange & Digestion](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-3-4-end-of-topic-test-substance-exchange-and-digestion.md) - [3.3.5 A-A* (AO3/4) - Substance Ex & Digestion](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-3-5-a-a-ao34-substance-ex-and-digestion.md) - 3.4 Mass Transport - [3.4.1 Haemoglobin](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-1-haemoglobin.md) - [3.4.2 Oxygen Transport](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-2-oxygen-transport.md) - [3.4.3 The Circulatory System](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-3-the-circulatory-system.md) - [3.4.4 The Heart](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-4-the-heart.md) - [3.4.5 Blood Vessels](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-5-blood-vessels.md) - [3.4.6 Cardiovascular Disease](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-6-cardiovascular-disease.md) - [3.4.7 Heart Dissection](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-7-heart-dissection.md) - [3.4.8 Xylem](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-8-xylem.md) - [3.4.9 Phloem](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-9-phloem.md) - [3.4.10 Investigating Plant Transport](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-10-investigating-plant-transport.md) - [3.4.11 End of Topic Test - Mass Transport](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-11-end-of-topic-test-mass-transport.md) - [3.4.12 A-A* (AO3/4) - Mass Transport](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-12-a-a-ao34-mass-transport.md) - [3.4.13 Diagnostic Misconceptions - Concentration Gradient](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-13-diagnostic-misconceptions-concentration-gradient.md) - [3.4.14 Diagnostic Misconceptions - Cardiac Cycle](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-14-diagnostic-misconceptions-cardiac-cycle.md) - [3.4.15 Diagnostic Misconceptions - Carrying Capacity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-15-diagnostic-misconceptions-carrying-capacity.md) - [3.4.16 Diagnostic Misconceptions - Translocation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/3-4-16-diagnostic-misconceptions-translocation.md) ### 4 Genetic Information & Variation - 4.1 DNA, Genes & Chromosomes - [4.1.1 DNA](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-1-1-dna.md) - [4.1.2 Genes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-1-2-genes.md) - [4.1.3 Non-Coding Genes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-1-3-non-coding-genes.md) - [4.1.4 The Genetic Code](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-1-4-the-genetic-code.md) - [4.1.5 A-A* (AO3/4) - DNA](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-1-5-a-a-ao34-dna.md) - 4.2 DNA & Protein Synthesis - [4.2.1 Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-2-1-protein-synthesis.md) - [4.2.2 Transcription & Translation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-2-2-transcription-and-translation.md) - [4.2.3 End of Topic Test - DNA, Genes & Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-2-3-end-of-topic-test-dna-genes-and-protein-synthesis.md) - [4.2.4 Exam-Style Question - Protein Synthesis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-2-4-exam-style-question-protein-synthesis.md) - [4.2.5 A-A* (AO3/4) - Coronavirus Translation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-2-5-a-a-ao34-coronavirus-translation.md) - [4.2.6 A-A* (AO3/4) - Transcription](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-2-6-a-a-ao34-transcription.md) - [4.2.7 A-A* (AO3/4) - Translation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-2-7-a-a-ao34-translation.md) - 4.3 Mutations & Meiosis - [4.3.1 Mutations](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-3-1-mutations.md) - [4.3.2 Meiosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-3-2-meiosis.md) - [4.3.3 A-A* (AO3/4) - Meiosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-3-3-a-a-ao34-meiosis.md) - [4.3.4 Meiosis vs Mitosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-3-4-meiosis-vs-mitosis.md) - [4.3.5 End of Topic Test - Mutations, Meiosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-3-5-end-of-topic-test-mutations-meiosis.md) - [4.3.6 A-A* (AO3/4) - DNA,Genes, CellDiv & ProtSynth](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-3-6-a-a-ao34-dnagenes-celldiv-and-protsynth.md) - [4.3.7 Diagnostic Misconceptions - Meiosis vs Mitosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-3-7-diagnostic-misconceptions-meiosis-vs-mitosis.md) - 4.4 Genetic Diversity & Adaptation - [4.4.1 Genetic Diversity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-4-1-genetic-diversity.md) - [4.4.2 Natural Selection](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-4-2-natural-selection.md) - [4.4.3 A-A* (AO3/4) - Natural Selection](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-4-3-a-a-ao34-natural-selection.md) - [4.4.4 Adaptations](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-4-4-adaptations.md) - [4.4.5 Investigating Natural Selection](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-4-5-investigating-natural-selection.md) - [4.4.6 End of Topic Test - Genetic Diversity & Adaptation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-4-6-end-of-topic-test-genetic-diversity-and-adaptation.md) - [4.4.7 A-A* (AO3/4) - Genetic Diversity & Adaptation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-4-7-a-a-ao34-genetic-diversity-and-adaptation.md) - 4.5 Species & Taxonomy - [4.5.1 Courtship Behaviour](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-5-1-courtship-behaviour.md) - [4.5.2 Phylogeny](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-5-2-phylogeny.md) - [4.5.3 Classification](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-5-3-classification.md) - [4.5.4 DNA Technology](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-5-4-dna-technology.md) - [4.5.5 A-A* (AO3/4) - Species & Taxonomy](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-5-5-a-a-ao34-species-and-taxonomy.md) - 4.6 Biodiversity Within a Community - [4.6.1 Biodiversity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-6-1-biodiversity.md) - [4.6.2 Index of diversity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-6-2-index-of-diversity.md) - [4.6.3 Agriculture](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-6-3-agriculture.md) - [4.6.4 End of Topic Test - Species,Taxonomy& Biodiversity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-6-4-end-of-topic-test-speciestaxonomyand-biodiversity.md) - [4.6.5 A-A* (AO3/4) - Species,Taxon&Biodiversity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-6-5-a-a-ao34-speciestaxonandbiodiversity.md) - 4.7 Investigating Diversity - [4.7.1 Genetic Diversity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-7-1-genetic-diversity.md) - [4.7.2 Quantitative Investigation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/4-7-2-quantitative-investigation.md) ### 5 Energy Transfers (A2 only) - 5.1 Photosynthesis - [5.1.1 Overview of Photosynthesis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-1-overview-of-photosynthesis.md) - [5.1.2 Photoionisation of Chlorophyll](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-2-photoionisation-of-chlorophyll.md) - [5.1.3 Production of ATP & Reduced NADP](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-3-production-of-atp-and-reduced-nadp.md) - [5.1.4 Cyclic Photophosphorylation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-4-cyclic-photophosphorylation.md) - [5.1.5 Light-Independent Reaction](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-5-light-independent-reaction.md) - [5.1.6 A-A* (AO3/4) - Photosynthesis Reactions](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-6-a-a-ao34-photosynthesis-reactions.md) - [5.1.7 Limiting Factors](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-7-limiting-factors.md) - [5.1.8 Photosynthesis Experiments](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-8-photosynthesis-experiments.md) - [5.1.9 End of Topic Test - Photosynthesis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-9-end-of-topic-test-photosynthesis.md) - [5.1.10 A-A* (AO3/4) - Photosynthesis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-1-10-a-a-ao34-photosynthesis.md) - 5.2 Respiration - [5.2.1 Overview of Respiration](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-1-overview-of-respiration.md) - [5.2.2 Anaerobic Respiration](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-2-anaerobic-respiration.md) - [5.2.3 A-A* (AO3/4) - Anaerobic Respiration](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-3-a-a-ao34-anaerobic-respiration.md) - [5.2.4 The Link Reaction](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-4-the-link-reaction.md) - [5.2.5 The Krebs Cycle](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-5-the-krebs-cycle.md) - [5.2.6 Oxidative Phosphorylation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-6-oxidative-phosphorylation.md) - [5.2.7 Respiration Experiments](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-7-respiration-experiments.md) - [5.2.8 End of Topic Test - Respiration](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-8-end-of-topic-test-respiration.md) - [5.2.9 A-A* (AO3/4) - Respiration](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-9-a-a-ao34-respiration.md) - [5.2.10 Diagnostic Misconceptions - Aerobic vs Anaerobic](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-2-10-diagnostic-misconceptions-aerobic-vs-anaerobic.md) - 5.3 Energy & Ecosystems - [5.3.1 Biomass](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-3-1-biomass.md) - [5.3.2 Production & Productivity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-3-2-production-and-productivity.md) - [5.3.3 Agricultural Practices](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-3-3-agricultural-practices.md) - 5.4 Nutrient Cycles - [5.4.1 Nitrogen Cycle](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-4-1-nitrogen-cycle.md) - [5.4.2 Phosphorous Cycle](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-4-2-phosphorous-cycle.md) - [5.4.3 Fertilisers & Eutrophication](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-4-3-fertilisers-and-eutrophication.md) - [5.4.4 End of Topic Test - Nutrient Cycles](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-4-4-end-of-topic-test-nutrient-cycles.md) - [5.4.5 A-A* (AO3/4) - Energy,Ecosystems&NutrientCycles](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/5-4-5-a-a-ao34-energyecosystemsandnutrientcycles.md) ### 6 Responding to Change (A2 only) - 6.1 Nervous Communication - [6.1.1 Survival](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-1-survival.md) - [6.1.2 Plant Responses](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-2-plant-responses.md) - [6.1.3 Animal Responses](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-3-animal-responses.md) - [6.1.4 Reflexes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-4-reflexes.md) - [6.1.5 End of Topic Test - Reflexes, Responses & Survival](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-5-end-of-topic-test-reflexes-responses-and-survival.md) - [6.1.6 Receptors](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-6-receptors.md) - [6.1.7 The Human Retina](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-7-the-human-retina.md) - [6.1.8 Control of Heart Rate](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-8-control-of-heart-rate.md) - [6.1.9 End of Topic Test - Receptors, Retina & Heart Rate](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-1-9-end-of-topic-test-receptors-retina-and-heart-rate.md) - 6.2 Nervous Coordination - [6.2.1 Neurones](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-1-neurones.md) - [6.2.2 Action Potentials](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-2-action-potentials.md) - [6.2.3 Speed of Transmission](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-3-speed-of-transmission.md) - [6.2.4 End of Topic Test - Neurones & Action Potentials](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-4-end-of-topic-test-neurones-and-action-potentials.md) - [6.2.5 Synapses](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-5-synapses.md) - [6.2.6 Types of Synapse](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-6-types-of-synapse.md) - [6.2.7 Medical Application](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-7-medical-application.md) - [6.2.8 End of Topic Test - Synapses](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-8-end-of-topic-test-synapses.md) - [6.2.9 A-A* (AO3/4) - Nervous Comm&Coord](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-2-9-a-a-ao34-nervous-commandcoord.md) - 6.3 Muscle Contraction - [6.3.1 Skeletal Muscle](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-3-1-skeletal-muscle.md) - [6.3.2 Sliding Filament Theory](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-3-2-sliding-filament-theory.md) - [6.3.3 Contraction](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-3-3-contraction.md) - [6.3.4 Slow & Fast Twitch Fibres](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-3-4-slow-and-fast-twitch-fibres.md) - [6.3.5 End of Topic Test - Muscles](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-3-5-end-of-topic-test-muscles.md) - [6.3.6 A-A* (AO3/4) - Muscle Contraction](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-3-6-a-a-ao34-muscle-contraction.md) - 6.4 Homeostasis - [6.4.1 Overview of Homeostasis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-1-overview-of-homeostasis.md) - [6.4.2 Blood Glucose Concentration](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-2-blood-glucose-concentration.md) - [6.4.3 Controlling Blood Glucose Concentration](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-3-controlling-blood-glucose-concentration.md) - [6.4.4 End of Topic Test - Blood Glucose](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-4-end-of-topic-test-blood-glucose.md) - [6.4.5 Primary & Secondary Messengers](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-5-primary-and-secondary-messengers.md) - [6.4.6 Diabetes Mellitus](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-6-diabetes-mellitus.md) - [6.4.7 Measuring Glucose Concentration](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-7-measuring-glucose-concentration.md) - [6.4.8 Osmoregulation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-8-osmoregulation.md) - [6.4.9 Controlling Blood Water Potential](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-9-controlling-blood-water-potential.md) - [6.4.10 ADH](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-10-adh.md) - [6.4.11 End of Topic Test - Diabetes & Osmoregulation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-11-end-of-topic-test-diabetes-and-osmoregulation.md) - [6.4.12 A-A* (AO3/4) - Homeostasis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-12-a-a-ao34-homeostasis.md) - [6.4.13 Diagnostic Misconceptions - Effect of ADH](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/6-4-13-diagnostic-misconceptions-effect-of-adh.md) ### 7 Genetics & Ecosystems (A2 only) - 7.1 Genetics - [7.1.1 Key Terms in Genetics](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-1-key-terms-in-genetics.md) - [7.1.2 Inheritance](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-2-inheritance.md) - [7.1.3 Linkage](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-3-linkage.md) - [7.1.4 Multiple Alleles & Epistasis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-4-multiple-alleles-and-epistasis.md) - [7.1.5 Chi-Squared Test](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-5-chi-squared-test.md) - [7.1.6 End of Topic Test - Genetics](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-6-end-of-topic-test-genetics.md) - [7.1.7 A-A* (AO3/4) - Genetics](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-7-a-a-ao34-genetics.md) - [7.1.8 Diagnostic Misconceptions - Dihybrid Inheritance](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-8-diagnostic-misconceptions-dihybrid-inheritance.md) - [7.1.9 Diagnostic Misconceptions - Sex Linkage](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-1-9-diagnostic-misconceptions-sex-linkage.md) - 7.2 Populations - [7.2.1 Populations](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-2-1-populations.md) - [7.2.2 Hardy-Weinberg Principle](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-2-2-hardy-weinberg-principle.md) - 7.3 Evolution - [7.3.1 Variation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-1-variation.md) - [7.3.2 Natural Selection & Evolution](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-2-natural-selection-and-evolution.md) - [7.3.3 End of Topic Test - Populations & Evolution](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-3-end-of-topic-test-populations-and-evolution.md) - [7.3.4 Types of Selection](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-4-types-of-selection.md) - [7.3.5 Types of Selection Summary](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-5-types-of-selection-summary.md) - [7.3.6 Overview of Speciation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-6-overview-of-speciation.md) - [7.3.7 Causes of Speciation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-7-causes-of-speciation.md) - [7.3.8 Diversity](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-8-diversity.md) - [7.3.9 End of Topic Test - Selection & Speciation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-9-end-of-topic-test-selection-and-speciation.md) - [7.3.10 A-A* (AO3/4) - Populations & Evolution](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-10-a-a-ao34-populations-and-evolution.md) - [7.3.11 Diagnostic Misconceptions - Types of Speciation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-3-11-diagnostic-misconceptions-types-of-speciation.md) - 7.4 Populations in Ecosystems - [7.4.1 Overview of Ecosystems](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-1-overview-of-ecosystems.md) - [7.4.2 Niche](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-2-niche.md) - [7.4.3 Population Size](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-3-population-size.md) - [7.4.4 Investigating Population Size](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-4-investigating-population-size.md) - [7.4.5 End of Topic Test - Ecosystems & Population Size](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-5-end-of-topic-test-ecosystems-and-population-size.md) - [7.4.6 Succession](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-6-succession.md) - [7.4.7 Conservation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-7-conservation.md) - [7.4.8 End of Topic Test - Succession & Conservation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-8-end-of-topic-test-succession-and-conservation.md) - [7.4.9 A-A* (AO3/4) - Ecosystems](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/7-4-9-a-a-ao34-ecosystems.md) ### 8 The Control of Gene Expression (A2 only) - 8.1 Mutation - [8.1.1 Mutations](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-1-1-mutations.md) - [8.1.2 Effects of Mutations](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-1-2-effects-of-mutations.md) - [8.1.3 Causes of Mutations](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-1-3-causes-of-mutations.md) - [8.1.4 Diagnostic Misconceptions - Gene Expression](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-1-4-diagnostic-misconceptions-gene-expression.md) - 8.2 Gene Expression - [8.2.1 Stem Cells](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-1-stem-cells.md) - [8.2.2 Stem Cells in Disease](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-2-stem-cells-in-disease.md) - [8.2.3 End of Topic Test - Mutation & Gene Epression](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-3-end-of-topic-test-mutation-and-gene-epression.md) - [8.2.4 A-A* (AO3/4) - Mutation & Stem Cells](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-4-a-a-ao34-mutation-and-stem-cells.md) - [8.2.5 Regulating Transcription](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-5-regulating-transcription.md) - [8.2.6 Epigenetics](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-6-epigenetics.md) - [8.2.7 Epigenetics & Disease](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-7-epigenetics-and-disease.md) - [8.2.8 Regulating Translation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-8-regulating-translation.md) - [8.2.9 Experimental Data](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-9-experimental-data.md) - [8.2.10 End of Topic Test - Transcription & Translation](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-10-end-of-topic-test-transcription-and-translation.md) - [8.2.11 Tumours](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-11-tumours.md) - [8.2.12 Correlations & Causes](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-12-correlations-and-causes.md) - [8.2.13 Prevention & Treatment](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-13-prevention-and-treatment.md) - [8.2.14 End of Topic Test - Cancer](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-14-end-of-topic-test-cancer.md) - [8.2.15 A-A* (AO3/4) - Gene Expression & Cancer](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-2-15-a-a-ao34-gene-expression-and-cancer.md) - 8.3 Genome Projects - [8.3.1 Using Genome Projects](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-3-1-using-genome-projects.md) - 8.4 Gene Technology - [8.4.1 Recombinant DNA](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-1-recombinant-dna.md) - [8.4.2 Producing Fragments](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-2-producing-fragments.md) - [8.4.3 Amplification](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-3-amplification.md) - [8.4.4 End of Topic Test - Genome Project & Amplification](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-4-end-of-topic-test-genome-project-and-amplification.md) - [8.4.5 Using Recombinant DNA](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-5-using-recombinant-dna.md) - [8.4.6 Medical Diagnosis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-6-medical-diagnosis.md) - [8.4.7 Genetic Fingerprinting](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-7-genetic-fingerprinting.md) - [8.4.8 End of Topic Test - Gene Technologies](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-8-end-of-topic-test-gene-technologies.md) - [8.4.9 A-A* (AO3/4) - Gene Technology](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/8-4-9-a-a-ao34-gene-technology.md) ### 9 Mathematical Skills - 9.1 Mathematical Skills - [9.1.1 Diagnostic Misconceptions - Converting Units](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/9-1-1-diagnostic-misconceptions-converting-units.md) - [9.1.2 Diagnostic Misconceptions - Correct Hypothesis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/9-1-2-diagnostic-misconceptions-correct-hypothesis.md) - [9.1.3 Diagnostic Misconceptions - Interpret Hypothesis](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/9-1-3-diagnostic-misconceptions-interpret-hypothesis.md) - [9.1.4 Diagnostic Misconceptions - Calculate Uncertainty](https://senecalearning.com/en-gb/revision-notes/a-level/biology/aqa/9-1-4-diagnostic-misconceptions-calculate-uncertainty.md)